Hopkins Lupus Cohort
霍普金斯狼疮队列
基本信息
- 批准号:9080241
- 负责人:
- 金额:$ 69.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-10 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAffectAfrican AmericanAlpha CellAmericanAngiographyAtherosclerosisBiological MarkersBiopsyCalcifiedCardiovascular DiseasesCardiovascular systemCaucasiansChronicClinicClinic VisitsClinicalClinical TrialsCollaborationsCoronaryCoronary ArteriosclerosisCoronary arteryCyclophosphamideDataDetectionDiseaseEnd stage renal failureEventFailureFoundationsFutureGrantImmune System DiseasesIndividualInterferon-alphaInterferonsInvestigationKidneyKidney DiseasesKidney FailureLeadLongitudinal StudiesLupusLupus NephritisMeasuresMedicineMonitorMycophenolateNephritisOrganOutcomePatientsPhase I Clinical TrialsPlasma CellsPlayProceduresProteomicsProtocols documentationPublishingRandomizedResearch PersonnelResolutionRiskRisk FactorsRoleSamplingSampling StudiesSerologicalSiteStagingSystemic Lupus ErythematosusTestingTimeTreatment outcomeUnited States National Institutes of HealthUrineValidationVascular Cell Adhesion Molecule-1VisitWorkX-Ray Computed Tomographybelimumabcardiovascular risk factorclinical research sitecohortexperiencegenetic signaturehigh riskinsightinterestlaboratory experimentmodifiable riskmortalityneutrophilpatient subsetspredicting responseprogramspublic health relevancetraiturinary
项目摘要
DESCRIPTION (provided by applicant): The Hopkins Lupus Cohort is a unique 27 year, 2300 SLE patient longitudinal cohort in which patients are followed by protocol every 3 months, allowing study of time-varying (lupus activity, cardiovascular risk factors and, treatment) variables: 1) In the last RO-1 we successfully developed and published computed tomography angiography (CTA) for detection of noncalcified plaque in SLE and showed that it was associated with same day measures of SLE activity. In this project, we will determine predictors of noncalcified plaque changes over time. We will bring an automated measure of noncalcified and calcified plaque burden to the clinic. 2) In the last RO-1 we successfully developed a consortium of U.S. sites interested in urine biomarkers of lupus nephritis activity, and discovered
and published new biomarkers including urinary VCAM-1. In this project we have enlarged the consortium, arranged collaboration with the GlaxoSmithKline belimumab lupus nephritis clinical trial to obtain longitudinal samples, and have begun our own urinary proteomics discovery program. We have already successfully brought urinary TWEAK to clinical trial stage, and anticipate bringing a panel of urinary biomarkers to the clinic for identification of lupus nephrits activity and prediction of treatment outcome. 3) In a past collaboration with Biogen-Idec we found that BAFF and neutrophil gene signatures associate with same day SLE activity and predict activity over the next year. In this project, we will continue that collaboration and determine whether these gene signatures are invariant in an individual or whether they change over time. If they change, we will evaluate the contributions of treatments and other variables. These investigations will demonstrate the utility of these signatures in indicating and predicting disease activity over time, so that they can be used in the clinic and in clinical trials.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MICHELLE A PETRI其他文献
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{{ truncateString('MICHELLE A PETRI', 18)}}的其他基金
Accelerating Medicines Partnership in RA and Lupus: Network Sites (UH2/UH3)
加速 RA 和狼疮药物合作:网络站点 (UH2/UH3)
- 批准号:
8851004 - 财政年份:2014
- 资助金额:
$ 69.83万 - 项目类别:
Accelerating Medicines Partnership in RA and Lupus: Network Sites (UH2/UH3)
加速 RA 和狼疮药物合作:网络站点 (UH2/UH3)
- 批准号:
9323818 - 财政年份:2014
- 资助金额:
$ 69.83万 - 项目类别:
Accelerating Medicines Partnership in RA and Lupus: Network Sites (UH2/UH3)
加速 RA 和狼疮药物合作:网络站点 (UH2/UH3)
- 批准号:
10200982 - 财政年份:2014
- 资助金额:
$ 69.83万 - 项目类别:
Accelerating Medicines Partnership in RA and Lupus: Network Sites (UH2/UH3)
加速 RA 和狼疮药物合作:网络站点 (UH2/UH3)
- 批准号:
9240807 - 财政年份:2014
- 资助金额:
$ 69.83万 - 项目类别:
PROSPECTIVE LUPUS COHORT STUDY OF DISEASE ACTIVITY AND PREDICTORS OF MORBIDITY
疾病活动性和发病预测因素的前瞻性狼疮队列研究
- 批准号:
7604532 - 财政年份:2006
- 资助金额:
$ 69.83万 - 项目类别:
COGNITIVE FUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS
系统性红斑狼疮的认知功能
- 批准号:
7604703 - 财政年份:2006
- 资助金额:
$ 69.83万 - 项目类别:
BRAIN CONNECTIONS: ADD-ON STUDY OF SERIAL BRAIN MRIS EVERY SIX MONTHS
大脑连接:每六个月进行一次连续脑 MRI 附加研究
- 批准号:
7604629 - 财政年份:2006
- 资助金额:
$ 69.83万 - 项目类别:
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