Accelerating Medicines Partnership in RA and Lupus: Network Sites (UH2/UH3)

加速 RA 和狼疮药物合作：网络站点 (UH2/UH3)

• 批准号: 9240807
• 负责人: MICHELLE A PETRI
• 金额: $ 11.95万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-24 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9240807
• 关键词: Address; Affect; American; Area; Atherosclerosis; Biological; Biological Markers; Biological Process; Cardiovascular system; Cessation of life; Characteristics; Chronic; Clinic Visits; Clinical; Clinical Data; Collaborations; Coupled; Cutaneous; Data; Data Analyses; Data Collection; Databases; Disease; Epidemiology; Flare; Genes; Health; Immune System Diseases; Institution; Kidney; Knowledge; Lead; Longitudinal Studies; Lung; Lupus; Measures; Medical; Medicine; Molecular Genetics; Monitor; Morbidity - disease rate; Musculoskeletal; Organ; Pathogenesis; Pathology; Pathway interactions; Patients; Peer Review; Phase; Positioning Attribute; Prevalence; Prognostic Marker; Protocols documentation; Publications; Quality of life; Recruitment Activity; Research; Resources; Sample Size; Sampling; Scheme; Site; Specimen; Subgroup; Systemic Lupus Erythematosus; Technology; Testing; Therapeutic; Time; Urine; Visit; Work; body system; clinical research site; cohort; gastrointestinal; genetic signature; insight; instrument; laboratory experiment; member; mortality; neuropsychiatry; patient subsets; phase 2 study; prevent; sample collection; targeted treatment; therapeutic development; therapeutic target

 DESCRIPTION (provided by applicant): The Hopkins Lupus Cohort is a longitudinal study of over 2,300 SLE patients followed every 3 months by protocol. Through our collaborative effort and partnership with different institutions and by supplying patient samples, we will help answers many unanswered questions. Identifying the biological pathways of renal progression could result in targeted therapeutics. Our partnership would also help in identifying genes or gene signatures associated with SLE disease activity or related organ damage could elucidate the pathways by which pathology occurs and result in targeted treatments offered to the correct subset of patients. Also, by Identifying pathways that lead to flares in disease can be used to develop therapeutics to prevent flares.

 描述（由适用提供）：霍普金斯狼疮队队是一项纵向研究，每3个月每3个月随访了2300多名SLE患者。通过我们与不同机构的合作努力和合作伙伴关系，并通过提供患者样本，我们将帮助回答许多未解决的问题。识别肾脏进展的生物学途径可能会导致靶向治疗。我们的伙伴关系还将有助于识别与SLE病活动或相关器官损害相关的基因或基因特征，可以阐明发生病理学的途径，并导致针对正确的患者子集提供的有针对性治疗。同样，通过鉴定导致疾病耀斑的途径可用于开发预防耀斑的疗法。