Accelerating Medicines Partnership in RA and Lupus: Network Sites (UH2/UH3)

加速 RA 和狼疮药物合作：网络站点 (UH2/UH3)

• 批准号: 9323818
• 负责人: MICHELLE A PETRI
• 金额: $ 51.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-24 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9323818
• 关键词: Address; Affect; American; Area; Atherosclerosis; Autoimmune Diseases; Biological; Biological Markers; Biological Process; Cardiovascular system; Cessation of life; Characteristics; Chronic; Clinic Visits; Clinical; Collaborations; Coupled; Cutaneous; Data; Data Analyses; Data Collection; Databases; Disease; Epidemiology; Flare; Freezing; Genes; Genetic; Institution; Kidney; Knowledge; Laboratories; Lead; Longitudinal Studies; Lung; Lupus; Measures; Medical; Medicine; Molecular; Monitor; Morbidity - disease rate; Musculoskeletal; Organ; Pathogenesis; Pathology; Pathway interactions; Patients; Peer Review; Phase; Positioning Attribute; Prevalence; Prognostic Marker; Protocols documentation; Publications; Quality of life; Recruitment Activity; Research; Resources; Sample Size; Sampling; Scheme; Site; Specimen; Subgroup; Systemic Lupus Erythematosus; Technology; Testing; Therapeutic; Time; Urine; Visit; Work; body system; clinical research site; cohort; gastrointestinal; genetic signature; insight; instrument; member; mortality; neuropsychiatry; patient subsets; phase 2 study; prevent; public health relevance; sample collection; targeted treatment; therapeutic development; therapeutic target

 DESCRIPTION (provided by applicant): The Hopkins Lupus Cohort is a longitudinal study of over 2,300 SLE patients followed every 3 months by protocol. Through our collaborative effort and partnership with different institutions and by supplying patient samples, we will help answers many unanswered questions. Identifying the biological pathways of renal progression could result in targeted therapeutics. Our partnership would also help in identifying genes or gene signatures associated with SLE disease activity or related organ damage could elucidate the pathways by which pathology occurs and result in targeted treatments offered to the correct subset of patients. Also, by Identifying pathways that lead to flares in disease can be used to develop therapeutics to prevent flares.

 描述（由申请人提供）：霍普金斯狼疮队列研究是一项纵向研究，包括2,300多名SLE患者，每3个月按方案随访一次。通过我们与不同机构的合作努力和伙伴关系，并通过提供患者样本，我们将帮助回答许多悬而未决的问题。确定肾脏进展的生物学途径可能导致靶向治疗。我们的合作伙伴关系还将有助于识别与SLE疾病活动或相关器官损伤相关的基因或基因特征，可以阐明病理发生的途径，并为正确的患者子集提供靶向治疗。此外，通过识别导致疾病爆发的途径，可以用于开发预防疾病爆发的治疗方法。