ACTG A5128

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This non-randomized, multi-center protocol is designed to 1) obtain appropriate consent for currently unspecified use of archived human biological materials (HBM) collected during all AACTG clinical trials, which may include genetic analyses, and 2) collect an additional blood sample as a source of human DNA for possible currently unspecified genetic analyses. The stored HBM will only be used for studies directly relevant to the health of persons with HIV infection, and the privacy of individual subjects will be protected. Each subject's involvement will only be limited to obtaining informed consent followed by a single blood sampling. If the subject agrees only to permitting archived samples to be used, the subject's involvement will only be limited to obtaining informed consent for the use of those specimens. This study is limited to current or prior ACTG study participants. SPECIFIC AIMS 1) To obtain informed consent to allow HBM collected during AACTG clinical trials to be used for currently unspecified analyses that may include genetic testing. 2) To obtain an additional whole blood sample to archive for future currently unspecified analyses that may include genetic testing.