ADHD IN GIRLS: NEUROIMAGING AND EXECUTIVE BEHAVIOR

女孩多动症：神经影像和执行行为

• 批准号: 7604716
• 负责人: MARTHA BRIDGE DENCKLA
• 金额: $ 0.15万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604716
• 关键词: Accounting; Age; Anatomy; Attention deficit hyperactivity disorder; Basal Ganglia; Behavior; Behavioral; Cerebellar vermis structure; Cerebellum; Cerebrum; Child; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Data; Data Set; Emotional; Enrollment; Funding; Gender; Globus Pallidus; Grant; Inferior; Institution; Interview; Magnetic Resonance Imaging; Modeling; Motor; Neurobiology; Participant; Preparation; Range; Reading; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Short-Term Memory; Source; Staging; Symptoms; Testing; Thinking; United States National Institutes of Health; boys; brain behavior; executive function; experience; frontal lobe; girls; interest; neuroimaging; neuropsychological; oculomotor; response; skills; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is evidence that girls with ADHD differ from boys with ADHD most strikingly in 1) academic and social-emotional and 2) neurobiological features. Building upon previous research experience concerning neurobiological features of boys with ADHD, this research project focuses on 2) neurobiology of girls with ADHD, with plans to derive data from quantitative volumetric/anatomic magnetic resonance imaging (aMRI) and assessments of executive behaviors, both motor/oculomotor and cognitive. To take gender into account, girls with ADHD will be compared with control girls as well as boys with and without ADHD. The age range for the 200 participants (50 in each group) will be 9.0 to 11.5 years; in addition, even at this young age, Tanner staging will be taken into consideration. Anatomic MRI regions of interest will be frontal lobe, basal ganglia, and cerebellum. It is hypothesized that girls with ADHD will differ from boys with ADHD at the levels of frontal lobe (showing anomalous assymetry only), and at the level of the basal ganglia (showing symmetrically smaller total caudate and globus pallidus volumes) while sharing with boys total cerebral and posterior inferior vermis reductions. Behavioral tasks, motor/oculomotor as well as cognitive, will be categorized into inhibitory control, response preparation, and working memory, functions thought to represent parallel frontostriatal and cerebellar interlocking circuits. It is hypothesized that girls with ADHD will be relatively more impaired in terms of response preparation and working memory than in terms of inhibition, a profile opposite to that of boys with ADHD. Gender-by-subtype interactions with respect to aMRI and behavioral datasets and the impact of emotional symptoms will be analyzed. Brain-behavior relationships as influenced by gender (modified by covariates as noted above) will be interpreted in terms of neurodevelopmental models of ADHD. This is a five-year study, enrolling 200 children. We will recruit 50 boys and 50 girls with ADHD, and 50 boys and 50 girls in a normal control group. All participants will receive structural/anatomic MRI (emphasizing frontal lobes, basal ganglia, and cerebellum), neuropsychological assessment emphasizing executive functions (including motor/oculomotor assessment), IQ testing, assessment of basic reading skills, and psychiatric interview.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 有证据表明，患有多动症的女孩与患有多动症的男孩在 1) 学业和社会情感以及 2) 神经生物学特征上最显着的不同。 基于之前关于患有 ADHD 的男孩的神经生物学特征的研究经验，该研究项目重点关注 2) 患有 ADHD 的女孩的神经生物学，计划从定量体积/解剖磁共振成像 (aMRI) 和执行行为（运动/动眼运动和认知）评估中获取数据。 考虑到性别，患有多动症的女孩将与对照女孩以及患有和不患有多动症的男孩进行比较。 200名参与者（每组50人）的年龄范围为9.0至11.5岁；另外，即使在这么小的年纪，坦纳的分期也会被考虑在内。 感兴趣的解剖 MRI 区域是额叶、基底神经节和小脑。 据推测，患有 ADHD 的女孩与患有 ADHD 的男孩在额叶水平（仅显示异常不对称）和基底神经节水平（显示对称较小的总尾状核和苍白球体积）方面有所不同，同时与男孩共享全脑和后下蚓部减少。 行为任务、运动/动眼神经以及认知，将被分为抑制控制、反应准备和工作记忆，这些功能被认为代表平行的额纹状体和小脑联锁回路。 据推测，患有多动症的女孩在反应准备和工作记忆方面的受损程度比在抑制方面的受损程度相对更大，这与患有多动症的男孩相反。 将分析关于 aMRI 和行为数据集的性别与亚型相互作用以及情绪症状的影响。 受性别影响的大脑行为关系（由上述协变量修改）将根据 ADHD 的神经发育模型进行解释。 这是一项为期五年的研究，招募了 200 名儿童。 我们将招募 50 名患有 ADHD 的男孩和 50 名女孩，以及 50 名男孩和 50 名女孩作为正常对照组。 所有参与者都将接受结构/解剖 MRI（强调额叶、基底神经节和小脑）、强调执行功能的神经心理学评估（包括运动/动眼神经评估）、智商测试、基本阅读技能评估和精神病学访谈。