Physician & Scientist Training in Developmental Genetics

描述（由申请人提供）：塔夫茨新英格兰医学中心（T-NEMC）和塔夫茨大学医学院（TUSM）的发育遗传学培训计划将为医生和博士生提供发育遗传学和遗传性疾病遗传学方面的强大培训，这些疾病可能影响胎儿，新生儿和孕产妇健康。拟议的25名教员来自T-NEMC和TUSM，包括拥有医学博士、博士和医学博士/博士学位的基础和转化研究人员。度。每年将招收3名由美国医学与社会医学委员会（acgme）认证的博士后，包括T-NEMC的母胎医学、新生儿-围产期医学和医学遗传学，以及3名来自TUSM萨克勒研究生生物医学科学学院遗传学和细胞与分子生理学的博士研究生。学员将分享共同的培训经验，严格暴露于实验和转化研究。该项目将促进儿科医生、医学遗传学家、治疗病人的产科医生和专注于疾病遗传机制的基础科学家之间的互动，从而帮助每个小组了解彼此工作的影响。研究培训将辅以关于遗传学基础、发育遗传学、伦理学的共同课程，以及由基础科学家和医生共同教授的关于遗传和发育疾病病理生物学的课程。研讨会、演讲工作坊、医院遗传学查房和职业咨询使该计划更加完善。通过整合基础和临床教师，建议的学员将获得更深入和更丰富的基本遗传机制和当代临床问题的知识。其目标是培养能够在多学科、转化环境中富有成效的基础科学教师和临床科学家，他们将成为独立的、受资助的研究人员，解决与面临发育残疾或遗传性疾病风险的母亲和儿童的健康有关的问题。

DESCRIPTION (provided by applicant): The Developmental Genetics Training Program at Tufts New England Medical Center (T-NEMC) and Tufts University School of Medicine (TUSM) will provide physicians and predoctoral students with strong training in developmental genetics and the genetics of inherited diseases that can impact fetal, neonatal, and maternal health. The proposed faculty of 25 is drawn from T-NEMC and TUSM, and includes basic and translational researchers who hold M.D., Ph.D., and M.D./Ph.D. degrees. Three postdoctoral trainees will be recruited from the ACGME-accredited fellowship programs in Maternal-Fetal Medicine, Neonatal-Perinatal Medicine, and Medical Genetics based at T-NEMC, and three predoctoral trainees will be recruited from the Ph.D. programs in Genetics and Cellular and Molecular Physiology at the Sackler School of Graduate Biomedical Sciences at TUSM each year. Trainees will share a common training experience with rigorous exposure to bench and translational research. The program will promote interaction among pediatricians, medical geneticists, and obstetricians who treat patients and basic scientists who focus on genetic mechanisms of disease, thereby helping each group understand the impact of the other's work. Research training will be complemented by common courses on fundamentals of genetics, developmental genetics, ethics, and a course on the pathobiology of genetic and developmental diseases that is co-taught by basic scientists and physicians. Seminars, presentation workshops, hospital-based genetics rounds, and career counseling round out the program. By integrating basic and clinical faculty, the proposed trainees will acquire a deeper and richer knowledge of basic genetic mechanisms and contemporary clinical problems. The goal is to produce basic science faculty who can be productive in multidisciplinary, translational environments and clinician scientists who will be become independent, funded investigators addressing problems relevant to the health of mothers and children at risk for developmental disability or inherited disorders.