Training Program in Trauma and Organ Injury

描述(申请人提供)：创伤性损伤仍然是一个对个人和社会产生巨大影响的重大公共卫生问题。创伤保健系统的一个重要组成部分是基础和临床研究。然而，由于训练有素的内科科学家数量的持续下降，创伤研究的未来进展可能会受到阻碍。这是创伤生物学和器官损伤博士后培训计划的第一次竞争性更新。该培训计划主要是为外科住院医师(PGY-III和IV)设计的，为他们提供为期两年(或三年)的密集研究，重点是与损伤相关的细胞功能障碍和多器官衰竭的机制。它将补充外科、细胞和分子生理学系现有的正在进行的创伤研究项目。该培训计划的目标是为高素质、积极进取的个人提供深入的知识基础和丰富的实验室经验，以促进在学术创伤研究领域取得成功、富有成效的独立职业生涯。培训计划的具体目标是：(1)在内分泌学和新陈代谢以及器官损伤和组织修复这两个主要学科之一提供全面的科学培训；(2)在调查过程的所有方面提供坚实的培训基础。该计划的管理结构由计划主任(Wiley Souba，医学博士)和副主任(Charles Lang，博士)协调。每名学员从外科、细胞和分子生理学、整形外科、内科和药理学等系中负责指导和评估学员进步的跨学科研究人员队伍中挑选共同导师(例如，一名临床科学家和一名基础科学家)。受训者将接受关于假设驱动的实验设计、技术专长和科学写作的所有方面的直接监督，并参加研究中伦理行为的必修课程。该计划的毕业生将是临床医生-科学家，他们拥有足够的科学成熟度，能够开始独立研究的职业生涯，并为提高创伤病理生理学方面的知识做出重大贡献。

DESCRIPTION (provided by applicant): Traumatic injury continues to be a major public health problem that impacts enormously on individuals and society. An essential component of the trauma health care system is basic and clinical research. However, future advancements in trauma research are likely to be hindered because of the continued decline in the number of well-trained physician-scientists. This is the first competing renewal of a postdoctoral training program in Trauma Biology and Organ Injury. The Training Program is designed primarily for surgical residents (PGY-III and IV) to provide them with an intensive two (or three)-year period of research focused on the mechanisms responsible for the cellular dysfunction and multiorgan failure associated with injury. It will complement the ongoing trauma research programs already present in the Departments of Surgery, and Cellular and Molecular Physiology. The goal of the training program is to provide highly qualified, motivated individuals with an in-depth knowledge base and intensive laboratory experience that will facilitate a successful, productive independent career in academic trauma research. The specific aims of the training program are to: (1) provide comprehensive scientific training focused in one of two major disciplines--Endocrinology and Metabolism, and Organ Injury and Tissue Repair; and (2) provide a strong training foundation in all aspects of the investigative process. The administrative structure of the program is coordinated by the Program Director (Wiley Souba, MD) and Associate Director (Charles Lang, PhD). Each trainee selects co-mentors (e.g., one clinician-scientist and one basic scientist) from an interdisciplinary cadre of established investigators within the Departments of Surgery, Cellular and Molecular Physiology, Orthopedics, Internal Medicine, and Pharmacology which are responsible for directing and evaluating the trainee's progress. Trainees will receive direct supervision regarding all aspects of hypothesis-driven experimental design, technical expertise, and scientific writing as well as participate in the required course on ethical conduct in research. Program graduates will be clinician-scientists who possess sufficient scientific maturity to embark on a career in independent research and make significant contributions to the advancement of knowledge concerning the pathophysiology of trauma.