Defining how signalling pathways cooperate to regulate organ size

定义信号通路如何合作调节器官大小

• 批准号: DP230101406
• 负责人: Prof Kieran Harvey
• 金额: $ 27.24万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101406
• 关键词: Defining; how; signalling; pathways; cooperate

Control of organ size is essential for organ function and organism viability, and varies greatly across the animal kingdom. This project aims to understand how three important signalling pathways co-ordinately regulate organ size during development and also limit aberrant growth. By applying genomics, genetics and bioinformatics techniques, this project aims to discover a core set of growth genes that are regulated by different signalling pathways and the mechanism by which transcription of these genes is repressed in order to eliminate faulty cells. Intended benefits are creation of jobs, new knowledge on fundamental principles of life and the stimulation of new research into organ size control.

器官大小的控制对器官功能和生物体生存能力至关重要，在动物王国中差异很大。该项目旨在了解三个重要的信号通路如何在发育过程中协调调节器官大小并限制异常生长。通过应用基因组学、遗传学和生物信息学技术，本项目旨在发现一组受不同信号通路调控的核心生长基因，以及抑制这些基因转录以消除缺陷细胞的机制。预期的好处是创造就业机会，关于生命基本原理的新知识，以及刺激对器官大小控制的新研究。