Training Grant in Lung Cell and Molecular Biology

描述（由申请人提供）： 该计划的主要目的是为医学博士提供至少2年半的肺生物学研究培训。和博士在博士后水平的候选人，因为他们准备追求在生物医学科学的学术研究生涯。大部分研究实习生将来自每年为哈佛肺和重症监护计划挑选的9名临床研究员。每个潜在的受训者，在项目主任的指导下，将花费长达4个月的时间访问研究人员和实验室，以选择一个明确的研究主题。然后，受训者将与一位高级研究导师合作，制定一个研究项目，包括一个可测试的机制假设，该假设将提交给培训补助金主任进行审查和批准。一旦项目获得批准，受训者将在培训期间与该导师一起工作。19名优秀的教师（包括MD和博士）来自基础科学和临床部门。培训的主要重点是在马萨诸塞州总医院医学部的肺部和重症监护室，但也可以在哈佛系统的任何地方进行，例如与麻省理工学院共享的布罗德研究所。四个专业研究小组，肺损伤的细胞和分子生物学，职业医学和分子生物学，肺部炎症和正电子发射断层扫描，根据他们选择的研究项目，为每个学员提供一个更加封闭和集中的环境。高级导师将密切关注学员的进展情况，并由项目主管进行定期审查。一个外部科学咨询委员会将每年审查整个计划，包括受训者独立于导师的行动。所有受训人员都必须参加科学调查负责任行为课程。作为培训的一部分，将提供呼吸道生物学、流行病学和生物统计学、伦理学和临床有效性方面的具体课程。一个互动的，多学科的国际公认的教师提供了一个强大的和令人兴奋的研究智力环境。在培训期结束时，每个受训者将成为熟练的，并在上述领域之一，如肺癌或哮喘，有适当的专门知识，能够在生物医学研究的学术环境中竞争进一步的培训或研究支持。

DESCRIPTION (provided by applicant): The main thrust of this program is to provide research training for a minimum of 2 1/2 years in pulmonary biology for M.D. and Ph.D. candidates at the postdoctoral level as they prepare to pursue academic research careers in biomedical sciences. The research trainees for the most part will come from the 9 clinical fellows selected each year for the Harvard Pulmonary and Critical Care Program. Each potential trainee, with guidance from the program directors, will spend up to 4 months visiting investigators and laboratories to choose a well-defined topic of investigation. The trainee will then work with a senior research mentor to develop a research project including a testable mechanistic hypothesis, which will be presented to the training grant directors for review and approval. Once the project is approved the trainee will work with that mentor for the duration of training. An outstanding faculty of 19 (both MD's and PhD's) is drawn from basic science and clinical departments. The primary focus of the training is in the Pulmonary and Critical Care Unit of the Department of Medicine at Massachusetts General Hospital, but can occur anywhere in the Harvard system such as at the Broad Institute shared with MIT. Four specialized research groups, cellular and molecular biology of lung injury, occupational medicine and molecular biology, lung inflammation, and positron emission tomography, provide each trainee a more cloistered and focused environment depending on their selected research project. The senior mentor will closely monitor the trainee's progress, with periodic review by program directors. An outside scientific advisory committee will review the entire program annually including movement of the trainee to become independent of their mentor. A course in Responsible Conduct of Scientific Investigation is required of all trainees. Specific courses in Biology of the Respiratory Tract, Epidemiology and Biostatistics, Ethics and Clinical Effectiveness will be offered as part of the training. An interactive, multi-disciplinary internationally recognized faculty provides a strong and exciting intellectual environment for research. At the conclusion of the training period, each trainee will have become adept and have appropriate expertise in one of the fields identified above, such as lung cancer or asthma, to be able to compete for further training or research support in an academic environment in biomedical research.