Multidisciplinary Training Program in Lung Disease

描述（由申请人提供）： 本申请是目前肺部疾病多学科培训计划（HL 07749）的竞争性更新。该计划的目标是培养杰出的生物医学科学家，他们调查肺部疾病的表现，机制，预防和治疗。该计划建议每年支持12名博士后研究员（M.D.s和Ph.D.s）。可供受训人员使用的调查方法包括适用于分子、细胞、组织、器官、整个动物和临床群体各级的学科。该计划利用来自密歇根大学医学院，公共卫生学院，生命科学研究所和工程学院的教师培训师。医学院的教员培训师被任命为内科，病理学，放射学，人类遗传学和分子与综合生理学部门。在流行病学和生物统计学系任命了公共卫生学院培训员。工程学院的培训师在生物医学工程系任命。主要导师和共同导师与受训者之间的密切关系是培训体验的核心。这个实验室的经验是由一个核心组的讲座，正式的课程工作，核心会议，并在负责任的研究行为，职业规划，沟通技巧和授权写作培训的补充。重点放在专门为个别学员设计的个人指导上。新的教师和核心讲座已经增加，以进一步巩固生物信息学，遗传学和纳米生物学的学科。相当大的重点放在多学科的互动，并提供机会，发展学术事业的科学需要的领域。在我们的计划增长的新兴领域包括微生物发病机制，移植生物学，祖细胞生物学和多机构疾病特异性临床研究网络。临床科学的博士后学员可以获得公共卫生学院的硕士学位。广泛的研究课题是提供给学员，包括趋化因子生物学，纤维化肺病的病理生物学，宿主防御机制，淋巴细胞-巨噬细胞相互作用，上皮细胞生物学，成纤维细胞生物学，蛋白酶生物学，类花生酸生物化学，粒细胞生物学，祖细胞生物学，流行病学，肺部疾病的结果，医生决策，医疗干预的经济评估，正确使用医疗技术和医德。研究员和辅导员由一个委员会审查，该委员会负责监测研究员的培训和职业发展，并促进辅导技能。该方案培训了5名少数民族学员（均为2004年以来注册的学员;目前有4名学员）。百分之八十（80%）的毕业生在过去的10年中培训目前在学术或同等职位，表明该计划的成功。

DESCRIPTION (provided by applicant): This application is a competitive renewal of the present Multidisciplinary Training Program in Lung Disease (HL07749). The goal of the program is produce outstanding biomedical scientists who investigate the manifestations, mechanisms, prevention, and treatment of pulmonary disorders. The program proposes to support 12 postdoctoral fellows (M.D.s and Ph.D.s) per year. The investigative approaches available to trainees include disciplines applicable at the molecular, cellular, tissue, organ, whole animal and clinical population levels. The program utilizes faculty trainers from the Medical School, School of Public Health, the Life Sciences Institute, and the College of Engineering at the Universityof Michigan. Medical School faculty trainers are appointed in the Departments of Internal Medicine, Pathology, Radiology, Human Genetics and Molecular and Integrative Physiology. The School of Public Health trainers are appointed in the Departments of Epidemiology and Biostatistics. The College of Engineering trainers are appointed in the Department of Biomedical Engineering. A close relationship between a primary mentor and a co-mentor(s) with the trainee is the core of the training experience. This laboratory experience is supplemented by a core group of lectures, formal course work, core conferences, and training in responsible research conduct, career planning, communication skills, and grant writing. Emphasis is placed on personal instruction specifically designed for individual trainees. New faculty and core lectures have been added to further solidify the disciplines of bioinformatics, genetics and nanobiology. Considerable emphasis has been placed on multidisciplinary interactions and providing opportunities to develop academic careers in areas of scientific need. Emerging areas of growth in our program include microbial pathogenesis, transplantation biology, progenitor cell biology, and multi-institutional disease-specific clinical networks for research. Postdoctoral trainees in the clinical sciences can acquire a Master's Degree from the School of Public Health. A broad range of research topics is available to trainees including chemokine biology, the pathobiology of fibrotic lung disease, host defense mechanisms, lymphocyte-macrophage interactions, epithelial cell biology, fibroblast biology, protease biology, eicosanoid biochemistry, granulocyte biology, progenitor cell biology, epidemiology, outcomes in lung disease, physician decision making, economic assessment of medical interventions, appropriate utilization of the medical technology and medical ethics. Fellows and mentors are reviewed by a committee that monitors the training and career development of fellows and promotes mentoring skills. The program has trained 5 minority trainees (all enrolled since 2004; 4 are current trainees). Eighty percent (80%) of graduates trained in the past 10 years are currently in academic or equivalent positions, indicative of the program's success.