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Relationship between Periodontal Disease and Gestational Diabetes Mellitus

牙周病与妊娠期糖尿病的关系

基本信息

批准号：
7424972
负责人：
Xu Xiong
金额：
$ 18.4万
依托单位：
TULANE UNIVERSITY OF LOUISIANA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-01 至 2010-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7424972
关键词：
Affect Area Bacteremia Birth Weight Birth trauma Blood Glucose Cardiovascular Diseases Caring Case-Control Studies Cesarean section Chronic Chronic Disease Clinical Confidence Intervals Dentists Depth Detection Development Diabetes Mellitus Disease Dystocia Elderly Future Gestational Diabetes Goals Human Immune response Infant Infection Inflammation Inflammatory Response Insulin Resistance Intervention Intervention Studies Morbidity - disease rate Non-Insulin-Dependent Diabetes Mellitus Odds Ratio Oral Examination Oral health Patients Perinatal Periodontal Diseases Pre-Eclampsia Pregnancy Pregnancy Outcome Pregnant Women Premature Birth Prevalence Qualifying Recruitment Activity Research Research Design Review, Systematic (PT)Risk Risk Factors Shoulder Source Speed Staging Systemic disease Testing Visit Woman base case control cost design improved novel prevent programs prospective

项目摘要

DESCRIPTION (provided by applicant): Gestational diabetes mellitus (GDM) is elevated blood glucose level (or hyperglycermia) with onset or first detection during pregnancy and represents more than 90% of all pregnancies complicated by diabetes. GDM complicates approximately 4% of all pregnancies in the U.S., affecting about 135,000 cases annually. GDM is associated with significantly increased risks of maternal and infant morbidity, including macrosomia (birth weight > 4000 g), hypertensive disorders in pregnancy (e.g., preeclampsia), cesarean section, preterm birth, shoulder dystocia and birth injury. Women with GDM are at a significantly higher risk of developing type 2 diabetes in their later life. Periodontal disease is the most common chronic disorder of infectious origin in humans and could affect about 20-50% of pregnant women. Periodontal disease results in bacteremia, inflammation, and a strong immune response, representing significant risk factors for the development of certain systemic diseases such as cardiovascular diseases, type 1 or 2 diabetes and adverse pregnancy outcomes. Because there are few previous studies that have examined the possible relationship between periodontal disease and GDM, we propose to conduct this case-control study to examine if periodontal disease is more prevalent in women with GDM than women without GDM. We will recruit 72 patients with GDM and 72 women without GDM during their antenatal care visits. After recruitment, an oral examination will be performed on all cases and controls by a qualified dentist. Periodontal status will be evaluated, and periodontal diseases will be defined by clinical parameters. The proportion of periodontal disease will be compared between women with and without GDM. The long-term goal of this research program is to develop intervention strategies that are based on the risk factors identified in the proposed study. Our study will contribute to an understanding of periodontal disease as a possible risk factor to GDM. Periodontal disease is preventable and curable. If periodontal disease is confirmed as a risk factor for GDM by our study, this will open the doors to intervention studies to prevent GDM. Improving oral health and treating periodontal disease before and during pregnancy may reduce maternal and perinatal morbidity associated with GDM and prevent type 2 diabetes after pregnancy.

描述（由申请人提供）：妊娠期糖尿病（GDM）是妊娠期间发病或首次检测到的血糖水平升高（或高血糖症），占所有妊娠合并糖尿病的90%以上。在美国，GDM使大约4%的怀孕复杂化，每年影响约135，000个病例。GDM与显著增加的孕产妇和婴儿发病率风险相关，包括巨大儿（出生体重> 4000 g）、妊娠期高血压疾病（例如，先兆子痫）、剖宫产、早产、肩难产和产伤。患有GDM的女性在以后的生活中患2型糖尿病的风险明显更高。牙周病是人类最常见的传染性慢性疾病，可能影响约20-50%的孕妇。牙周病导致菌血症，炎症和强烈的免疫反应，代表某些全身性疾病如心血管疾病，1型或2型糖尿病和不良妊娠结局发展的重要风险因素。由于以前很少有研究牙周病和GDM之间可能存在的关系，我们建议进行这种病例对照研究，以检查牙周病是更普遍的女性GDM比女性没有GDM。我们将招募72名GDM患者和72名非GDM女性进行产前检查。招募后，将由合格的牙医对所有病例和对照组进行口腔检查。将评估牙周状况，并通过临床参数定义牙周疾病。牙周病的比例将在患有和不患有GDM的女性之间进行比较。本研究计划的长期目标是根据拟议研究中确定的风险因素制定干预策略。我们的研究将有助于了解牙周病作为一个可能的危险因素，以GDM。牙周病是可以预防和治愈的。如果我们的研究证实牙周病是GDM的一个危险因素，这将为预防GDM的干预研究打开大门。改善口腔健康和治疗牙周病怀孕前和怀孕期间可能会降低孕产妇和围产期发病率与GDM和预防2型糖尿病怀孕后。