Diabetes Endocrinology Research Center

总体描述(由申请人提供)： 我们寻求在贝勒医学院建立糖尿病内分泌学研究中心(DERC)。DERC将促进糖尿病在不同的生物医学研究基地中的研究，这些研究涵盖临床代谢和营养、1型和2型糖尿病及其大血管和微血管并发症、脂类稳态、脂肪生物学和能量代谢、基础分子和细胞生物学、分子内分泌学、胰岛生物学和基因治疗。贝勒医学院在糖尿病/内分泌学方面拥有非常强大的持续生物医学研究基础，可分为四个主要领域：[1]临床糖尿病研究，[2]基础和翻译研究，[3]分子内分泌学和[4]脂肪生成，成员代表10个系和多个学科。DERC将促进糖尿病/内分泌学研究人员之间的互动和合作，并吸引非糖尿病研究人员致力于糖尿病研究。它将与贝勒现有的研究中心和NIH培训计划互动并加强，并建立新的丰富计划。在学院的支持下，PI(陈博士)在2004年建立了一个非常成功的DERC试点和可行性(P/F)计划，并在过去两年里利用学院内部资金支持了从10个系的78个申请中挑选出来的4个P/F项目(2004年44个申请中各2个，2006年34个申请中各2个)。DERC将通过以下研究核心实验室支持糖尿病研究：临床翻译调查、基因芯片、生物统计学和生物信息学、蛋白质组学、基因载体、小鼠 表型和非人类灵长类动物(与圣安东尼奥西南生物医学研究基金会合作)，这将支持DERC教职员工和P/F项目的糖尿病研究。这个 DERC将进一步扩大贝勒医学院的糖尿病研究基础，同时与德克萨斯医学中心和美国大西南地区的其他项目和机构产生强大的协同效应。

DESCRIPTION, OVERALL (provided by applicant): We seek to establish a Diabetes Endocrinology Research Center (DERC) at Baylor College of Medicine. The DERC will promote diabetes research among a diverse biomedical research base that spans clinical metabolism and nutrition, type 1 and type 2 diabetes and their macrovascular and microvascular complications, lipid homeostasis, adipose biology and energy metabolism, basic molecular and cellular biology, molecular endocrinology, islet biology and gene therapy. Baylor College of Medicine has an extremely strong ongoing biomedical research base in diabetes/endocrinology that can be categorized into four major areas: [1] clinical diabetes research, [2] basic and translational research, [3] molecular endocrinology, and [4] adipogenesis, with membership representing 10 departments and multiple disciplines. The DERC will foster interactions and facilitate collaboration among diabetes/endocrinology researchers, and entice nondiabetes researchers to commit to diabetes research. It will interact with and strengthen existing Research Centers and NIH Training Programs at Baylor and set up new enrichment programs. With College support, the PI (Dr. Chan) set up a highly successful pilot DERC Pilot & Feasibility (P/F) Program in 2004 and, in the last two years, has used internal College funds to support 4 P/F projects selected from 78 applications (2 each from 44 applications in 2004 and 34 applications in 2006) from 10 departments. The DERC will support diabetes research through the following Research Core Laboratories: Clinical Translational Investigation, Microarray, Biostatistics and Bioinformatics, Proteomics, Gene Vector, Mouse Phenotyping, and Nonhuman Primate (in collaboration with the Southwest Foundation for Biomedical Research in San Antonio), that will support diabetes research of DERC faculty and of P/F projects. The DERC will further broaden the diabetes research base at Baylor College of Medicine, while generating strong synergism with other programs and institutions in the Texas Medical Center and in the greater Southwest United States.