REVERSAL OF OBESITY BY TARGETED ABLATION OF ADIPOSE TISSUE

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 一种蛋白质已被分离出来，它附着在脂肪组织的血管上。这种蛋白质经过精心设计，一旦附着在血管中的某个部位，就会导致血管死亡。结果是脂肪组织消失，因为它失去了血液供应。原理已在小鼠身上得到证实，我们希望在肥胖狒狒身上测试该化合物。该化合物将给药 28 天。在用消脂激素治疗之前和结束时，将测量身体脂肪和与脂肪和碳水化合物代谢相关的代谢激素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A protein has been isolated that attaches to a site on blood vessels in fat tissue. The protein has been engineered so that once it attaches to the site in the blood vessel, it causes the blood vessel to die. The result is that fat tissue disappears because it has lost its blood supply. Proof of principle has been demonstrated in mice and we wish to test the compound in obese baboons. The compound will be administered for 28 days. Measures of body fats and metabolic hormones related to fat and carbohydrate metabolism will be made prior to and at the conclusion of treatment with the fat ablating hormone.