REVERSAL OF OBESITY BY TARGETED ABLATION OF ADIPOSE TISSUE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 一种蛋白质已经被分离出来，这种蛋白质附着在脂肪组织的血管上。这种蛋白质经过改造，一旦附着到血管中的位置，就会导致血管死亡。其结果是脂肪组织消失，因为它失去了血液供应。原理上的证据已经在老鼠身上得到了证明，我们希望在肥胖的狒狒身上测试这种化合物。该化合物的服用期限为28天。与脂肪和碳水化合物代谢有关的体脂和代谢激素的测量将在脂肪消融激素治疗之前和结束时进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A protein has been isolated that attaches to a site on blood vessels in fat tissue. The protein has been engineered so that once it attaches to the site in the blood vessel, it causes the blood vessel to die. The result is that fat tissue disappears because it has lost its blood supply. Proof of principle has been demonstrated in mice and we wish to test the compound in obese baboons. The compound will be administered for 28 days. Measures of body fats and metabolic hormones related to fat and carbohydrate metabolism will be made prior to and at the conclusion of treatment with the fat ablating hormone.