Field Deployable, Automatic, EEG Seizure Detector and Brain Dysfunction Monitor

描述（由申请人提供）：这项快速通道SBIR提案的总体目标是开发一种便携式、低成本、可现场部署、基于脑电图的自动癫痫发作探测器和脑功能障碍监测仪，用于大规模伤亡条件下的普通平民。预计该系统将作为癫痫发作快速和积极管理的重要组成部分，对改善恐怖袭击中神经毒剂暴露引起的神经病理至关重要。该系统的开发将基于我们几项高度相关技术的进一步增强和整合，包括商业级便携式、低成本和强大的术中意识监测器，该监测器可以在需要麻醉的手术过程中实时跟踪患者的皮层活动。癫痫检测算法将利用我们与美国国立卫生研究院和美国陆军正在进行的项目，我们正在开发一种新型的癫痫识别算法，可以在标准笔记本电脑上实时操作。系统的鲁棒性将通过结合我们的新的伪迹识别和去除算法得到增强，这些算法目前由NINDS支持。第一阶段将开发一种坚固耐用、便携、可现场部署的癫痫检测器，包括一个8通道脑电图设备，该设备连接到一台笔记本电脑上，该笔记本电脑执行癫痫检测，并以图形格式显示癫痫状态。第二阶段将进一步小型化脑电图病人单元，该单元还将包含板载数据处理能力（DSP）和附加屏幕，可以实时显示癫痫发作状态。该装置还将包含数据存储和无线功能，允许它与一个可以同时监控几个病人单元的中心站通信。在每个阶段结束时，开发的原型将进行广泛的模拟和实际临床评估。特别是，第2阶段系统将在克利夫兰诊所和克利夫兰大学医院两大保健机构的急诊科（ED）进行试验，共有255名入住急诊科并需要进行紧急脑电图检查的患者。根据该项目开发的便携式、低成本、可现场部署、基于脑电图的自动癫痫发作探测器和脑功能障碍监测器的目标是在大规模伤亡条件下为普通平民提供服务。预计该系统将作为癫痫发作快速和积极管理的重要组成部分，对改善恐怖袭击中神经毒剂暴露引起的神经病理至关重要。同样的技术也适用于战场上遭受神经毒气攻击的军事人员的脑电图监测和癫痫检测。最后，开发的系统最终可以成为急诊科一般护理的一部分，特别是对于精神状态改变的患者和那些怀疑有非惊厥性癫痫发作和脑功能障碍的患者。

DESCRIPTION (provided by applicant): The overall goal of this Fast-Track SBIR proposal is to develop a portable, low-cost, field-deployable, automatic EEG-based seizure detector and brain dysfunction monitor for general civilian population under mass casualty conditions. It is envisioned that this system will be used as an essential component of rapid and aggressive management of seizures, crucial to ameliorate neuropathology caused by nerve agent exposure in a terrorist attack. The development of this system will be based on further enhancement and integration of our several highly relevant technologies, including a commercial-grade portable, low cost, and robust intra-operative consciousness monitor that tracks patient's cortical activity in real-time during surgical procedures requiring anesthesia. The seizure detection algorithms will take advantage of our ongoing projects with the NIH and the ARMY where we are developing a novel class of seizure identification algorithms that can operate in real-time on a standard laptop. The robustness of the system will be enhanced by incorporating our novel artifact identification and removal algorithms currently supported by NINDS. The Phase I stage will develop a rugged, portable, field-deployable, seizure detector comprising of an 8- channel EEG device that is attached to a laptop that performs seizure detection and will display the seizure status in graphical format. Phase II will further miniaturize the EEG patient unit which will also contain an onboard data processing capability (DSP) and an attached screen that will display seizure status in real-time. The unit will also contain data storage and a wireless capability allowing it to communicate with a centralized station that can monitor several of these patient units simultaneously. The developed prototypes at the end of each Phase will undergo extensive simulated and actual clinical evaluations. In particular, The Phase II system will be tested in the Emergency Departments (ED) of two major health facilities, The Cleveland Clinic and University Hospitals of Cleveland, with a combined 255 patients who have been admitted to the ED and who are in need of an emergency EEG examination. The portable, low-cost, field-deployable, automatic EEG-based seizure detector and brain dysfunction monitor to be developed under this project is aimed for general civilian population under mass casualty conditions. It is envisioned that this system will be used as an essential component of rapid and aggressive management of seizures, crucial to ameliorate neuropathology caused by nerve agent exposure in a terrorist attack. The same technology is also applicable for EEG monitoring and seizure detection of military personnel subjected to a nerve gas attack in the battlefield. Finally, the developed system can be eventually become part of the general care in the Emergency Department and particularly in patients with altered mental status and those suspicious of having non-convulsive seizures and brain dysfunction.