Ambulatory Sleepiness & Apnea Propensity Evaluation Syst

动态嗜睡

• 批准号: 6884221
• 负责人: MO MODARRES
• 金额: $ 21.95万
• 依托单位: CLEVELAND MEDICAL DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-05 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6884221
• 关键词: attention; clinical research; computer assisted diagnosis; computer program /software; computer system design /evaluation; computer system hardware; diagnosis design /evaluation; disease /disorder proneness /risk; human subject; patient oriented research; sleep apnea; sleep disorders

DESCRIPTION: The overall goal of this project is to develop a novel ambulatory, easy-to-administer, short-duration, and highly quantitative method of evaluating/screening an individual for excessive sleepiness, as well as his/her propensity for developing sleep-disordered breathing (i.e., sleep apneas/hypopneas). The proposed Ambulatory Sleepiness & Apnea Propensity (ASAP(tm)) evaluation system is a paradigm change in terms of the entire screening/assessment method for the presence of sleep-disordered breathing and excessive sleepiness that affect millions (prevalence of Obstructive Sleep Apnea, OSA, alone is around 4%). It is an innovative approach that simultaneously produces two indices related to (1) excessive daytime sleepiness, and (2) the likelihood of demonstrating respiratory disturbances during sleep, by combining the highly quantitative information acquired during a short duration (approximately 15 minute) Maintenance of Alertness Test (MAT) with a novel analysis of the wake to sleep transition (both neurological and respiratory signals) during a short duration (approximately 30 minutes) subsequent nap. Thus, the "Alertness Index" provided by MAT is combined with the "Sleepiness Index" obtained from the subsequent nap to produce an overall "Excessive Daytime Sleepiness Index". The nap also produces an overall "Apnea-Propensity Index" by a novel and automatic analysis of respiratory variability around the start of sleep onset period. The applicants have provided preliminary analysis of PSG data from patients with a variety of OSA severity (normal, mild, moderate, and severe) showing that the Apnea-Propensity Index, computed around the first wake-sleep transition, demonstrates good correlation (Correlation Coef.=86%) with the clinical indicator of severity of OSA (Apnea/Hypopnea Index, computed from the entire night PSG). The proposed ASAP(tm) system can be conveniently utilized in many locations ranging from sleep laboratories to a psychiatry and neurology office/clinic, primary care physician's office, and health-care stations within workplace. Phase I of this project will focus on developing the hardware/software component of ASAP(tm), as well as its innovative algorithms for EDS and apnea screening/monitoring. The system will also undergo an extensive clinical evaluation at a sleep disorders center with both normal and OSA patients.

描述：这个项目的总体目标是开发一种新的、易于管理、持续时间短和高度定量的方法来评估/筛查个人的过度嗜睡，以及他/她发展睡眠呼吸紊乱(即睡眠呼吸暂停/低呼吸)的倾向。拟议的动态嗜睡和呼吸暂停倾向(ASAP(Tm))评估系统是对影响数百万人的睡眠呼吸紊乱和过度嗜睡的整个筛查/评估方法的范例改变(仅阻塞性睡眠呼吸暂停，OSA的患病率就约为4%)。这是一种创新的方法，通过将在短时间(约15分钟)保持警觉性测试(MAT)期间获得的高度定量信息与对短时间(约30分钟)小睡后觉醒到睡眠的转变(神经和呼吸信号)的新颖分析相结合，同时产生与(1)白天过度嗜睡和(2)在睡眠期间表现出呼吸障碍的可能性相关的两个指数。因此，MAT提供的“警觉指数”与从随后的午睡中获得的“嗜睡指数”相结合，产生一个整体的“白天过度嗜睡指数”。NAP还通过一种新颖的、自动分析开始入睡时期的呼吸变异性的方法，产生了一个总体的“呼吸暂停倾向指数”。申请人提供了对不同OSA严重程度(正常、轻度、中度和严重)患者的PSG数据的初步分析，结果表明，在第一次觉醒-睡眠转换前后计算的呼吸暂停倾向指数与OSA严重程度的临床指标(呼吸暂停/低呼吸指数，根据整夜PSG计算)显示出良好的相关性(相关系数=86%)。建议的ASAP(Tm)系统可以在许多地点方便地使用，从睡眠实验室到精神病学和神经病学办公室/诊所、初级保健医生办公室和工作场所内的保健站。该项目的第一阶段将侧重于开发ASAP(Tm)的硬件/软件组件，以及用于EDS和呼吸暂停筛查/监测的创新算法。该系统还将在睡眠障碍中心接受广泛的临床评估，包括正常患者和阻塞性睡眠呼吸暂停综合征患者。

项目成果

EEG slow waves in traumatic brain injury: Convergent findings in mouse and man

• DOI: 10.1016/j.nbscr.2016.06.001
• 发表时间: 2017-01-01
• 期刊: Neurobiology of Sleep and Circadian Rhythms
• 作者: Modarres, Mo H.;Kuzma, Nicholas N.;Lim, Miranda M.
• 通讯作者: Lim, Miranda M.