Wireless EEG and Attention Evaluation System for ADHD

本项目拟开发一种可移动、无线、神经心理学评估系统，用于儿童注意缺陷障碍（ADD）和注意缺陷多动障碍（ADHD）的定量筛查和评估。所提出的系统将能够采集和分析EEG（脑电图），ERP（事件相关EEG电位）和注意力变量，用于客观的ADHD筛查，诊断和评估药物的有效性。根据该计划开发的神经心理学评估系统基本上将多通道无线EEG/ERP采集和分析设备与基于神经网络的注意力连续性能测试（CPT）相结合。该组合系统将能够被精神科医生和神经科医生用于一些短期测试协议，这些测试协议将允许检测精神分裂症的行为和神经学体征。 注意力缺陷多动症，同时排除嗜睡和其他神经缺陷（如癫痫发作）。 申报系统将基于Cleveland Medical Devices Inc.开发。（CMDI）最先进的微型生物遥测技术沿着其新颖的生物信号处理和解释软件。特别是，该系统将利用CMDI正在进行的无线警觉性监测项目，并将该系统适用于ADHD人群。在第一阶段，开发的ADHD系统将用于30名ADHD患者和15名年龄匹配的正常受试者的广泛临床试验。

This proposal intends to develop an ambulatory, wireless, neuropsychological assessment system for quantitative screening and evaluation of children with attention deficit disorder (ADD) and attention deficit hyperactivity disorder (ADHD). The proposed system would be capable of acquiring and analyzing EEG (Electroencephalograph), ERP (Event-related EEG potential), and attention variables for an objective ADHD screening, diagnosis, and assessment of the effectiveness of medication. The neuropsychological assessment system to be developed under this program essentially combines a multi-channel wireless EEG/ERP acquisition and analysis device with an auditory-based continuous performance test (CPT) of attention. The combined system will be capable of being utilized by the psychiatrists and neurologists in a number of short-duration test protocols that will allow for detection of behavioral and neurological signs of ADHD while ruling out sleepiness and other neurological deficiencies (such as epileptic seizures). The proposed system will be developed based on the Cleveland Medical Devices Inc. (CMDI) state-of-the-art miniature bio-telemetry technology along with its novel bio-signal processing and interpretation software. In particular, the system will take advantage of the CMDI on-going wireless alertness monitoring project and will adapt that system for the ADHD population. During Phase I, the developed ADHD system will be used in an extensive clinical trial with 30 ADHD patients and 15 age-matched normal subjects.