Molecular basis for conjugative transfer of antibiotic resistance genes in Gram positive pathogens

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There has been growing concern about the increasing level of antibiotic resistance in bacterial pathogens. We will use a model genetic element to determine the mechanism by which an important class of pathogenic bacteria can acquire new resistance genes by a process known as horizontal gene transfer. The project will significantly enhance our understanding of how major hospital and community acquired pathogenic bacteria can rapidly evolve to become resistant to different antimicrobial agents.