The Biochemistry and Cell Biology of Metabolic Diseases

描述(由申请人提供)： 由糖尿病和代谢性疾病研究中心(DMDRC)赞助的机构NRSA计划为受过科学训练的(博士)提供多学科的研究生培训机会。并接受过临床培训(医学博士)运用最先进的生物化学、细胞和分子生物学方法，获得代谢性疾病研究方面的专业知识。培训的机会包括糖尿病和胰岛素的作用、蛋白质代谢、疾病状态下的G蛋白偶联受体作用、细胞信号、RAS和MAP激酶调节。专业知识来自9个系的27名培训员，他们在6个主要学科(生理学、药理学、生物化学、分子生物学和细胞生物学、生物医学工程)进行基础/临床研究。培训教师支持这样的宗旨，即在内分泌和代谢疾病的不同和多方面领域取得成功的研究生涯需要在这五个主要学科中建立广泛的基础背景，以及能够接受超越个人直接专业限制的战略的混合视角。培训主要是作为个别培训师积极、支持性研究计划的参与者，以及作为DMDRC成员的更广泛基础的培训。受训人员积极参加每周一次的跨部门研讨会、小型研讨会、专门领域(内分泌学、细胞信号)的期刊俱乐部，以及定期举行的科学会议，在会上介绍原创研究的报告。受训人员(每年8名)将主要是医学(医学博士)。或者对利用这些机会表现出浓厚兴趣的博士毕业生。重点是大力招聘妇女和任职人数偏低的少数群体。受训者是根据他们以仔细和批判性的方式进行原创研究的能力、他们的论文和/或先前工作的性质和质量以及推荐人的建议来挑选的。竞争激烈的申请者参观校园并举办研讨会。设施包括现代化实验室(&gt；300,000 N.S.F.)为原创研究工作做好准备。在转基因和KO siRNA小鼠、蛋白质组学(MALDI和QToF质谱学)和结构生物学、双光子显微镜和成像分析、FCS、微阵列、MRI/PET等方面存在独特的高级培训机会。DMDRC T32项目赞助生物伦理培训、职业发展和规划。DMDRC培训计划得到了全校的大力支持。

DESCRIPTION (provided by applicant): The institutional NRSA program sponsored by the Diabetes & Metabolic Diseases Research Center (DMDRC) offers multidisciplinary post-graduate training opportunities to the scientifically-trained (Ph.D.) and clinically-trained (M.D.) to acquire expertise in the study of metabolic diseases using state-of-the-art approaches of biochemistry, cell and molecular biology. Opportunities for training include diabetes & insulin action, protein metabolism, G-protein-coupled receptor action in disease states, cell signaling, Ras and MAP kinase regulation. Expertise is derived from 27 trainers from 9 departments with basic/clinical research in 6 major disciplines (physiology, pharmacology, biochemistry, molecular biology & cell biology, biomedical engineering). The training faculty support the tenet that a successful research career in the diverse and multifaceted area of endocrine and metabolic diseases requires a broadly-based background founded in these five major disciplines as well as a hybrid perspective which is receptive to strategies transcending the limits of one's immediate specialty. Training is principally as participants in vigorous, supportive research programs of individual trainers as well as more-broadly-based training as DMDRC members. Trainees actively participate in weekly interdepartmental seminars, minisymposia, journal clubs in specialized areas (endocrinology, cell signaling), and periodic scientific meetings where reports on original research are presented. The trainees (8 per year) will be principally medical (M.D.) or Ph.D. graduates who demonstrate a keen interest in taking advantage of these opportunities. Emphasis is placed on the vigorous recruitment of women and underrepresented minorities. Trainees are selected based upon their ability to conduct original research in a careful and critical manner, the nature and quality of their thesis and/or prior work, and recommendations by referees. Competitive applicants visit the campus and present a seminar. Facilities include modem laboratories (>300,000 n.s.f.) equipped for original research endeavors. Unique opportunities exist for advanced training in transgenic and KO siRNA mice, proteomics (MALDI and QToF mass spectrometry) & structural biology, 2-photon microscopy & imaging analysis, fcs, microarray, MRI/PET, etc.. The DMDRC T32 program sponsors bioethics training, career building, and planning. The DMDRC training program enjoys strong University-wide support.