The Biochemistry and Cell Biology of Metabolic Diseases

描述（由申请人提供）： 由糖尿病和代谢疾病研究中心（DMDRC）赞助的机构NRSA计划为科学培训（博士）提供多学科研究生培训机会。临床训练（M.D.）获得使用生物化学，细胞和分子生物学的最先进方法研究代谢疾病的专业知识。培训机会包括糖尿病和胰岛素作用，蛋白质代谢，疾病状态下的G蛋白偶联受体作用，细胞信号传导，Ras和MAP激酶调节。专业知识来自9个部门的27名培训师，他们在6个主要学科（生理学，药理学，生物化学，分子生物学和细胞生物学，生物医学工程）进行基础/临床研究。培训教师支持的宗旨，即在内分泌和代谢疾病的多样性和多方面的领域成功的研究生涯需要在这五个主要学科中建立广泛的背景，以及接受超越一个人的直接专业限制的策略的混合视角。培训主要是作为个体培训师的积极，支持性研究计划的参与者，以及作为DMDRC成员的更广泛的培训。学员积极参加每周一次的跨部门研讨会、minisymopsia、专业领域（内分泌学、细胞信号）的期刊俱乐部以及定期的科学会议，在这些会议上提交原创研究报告。受训人员（每年8人）将主要是医学博士。或博士对利用这些机会表现出浓厚兴趣的毕业生。重点是大力招募妇女和代表性不足的少数族裔。学员的选择是基于他们以谨慎和批判的方式进行原创性研究的能力，他们的论文和/或先前工作的性质和质量，以及裁判的建议。有竞争力的申请者参观校园并举办研讨会。设施包括现代化实验室（> 300，000 n. s.f.）为原创性的研究工作做好准备。转基因和KO siRNA小鼠，蛋白质组学（MALDI和QToF质谱）和结构生物学，双光子显微镜和成像分析，fcs，微阵列，MRI/PET等的高级培训存在独特的机会。DMDRC T32计划赞助生物伦理学培训，职业建设和规划。DMDRC培训计划享有强大的大学范围内的支持。

DESCRIPTION (provided by applicant): The institutional NRSA program sponsored by the Diabetes & Metabolic Diseases Research Center (DMDRC) offers multidisciplinary post-graduate training opportunities to the scientifically-trained (Ph.D.) and clinically-trained (M.D.) to acquire expertise in the study of metabolic diseases using state-of-the-art approaches of biochemistry, cell and molecular biology. Opportunities for training include diabetes & insulin action, protein metabolism, G-protein-coupled receptor action in disease states, cell signaling, Ras and MAP kinase regulation. Expertise is derived from 27 trainers from 9 departments with basic/clinical research in 6 major disciplines (physiology, pharmacology, biochemistry, molecular biology & cell biology, biomedical engineering). The training faculty support the tenet that a successful research career in the diverse and multifaceted area of endocrine and metabolic diseases requires a broadly-based background founded in these five major disciplines as well as a hybrid perspective which is receptive to strategies transcending the limits of one's immediate specialty. Training is principally as participants in vigorous, supportive research programs of individual trainers as well as more-broadly-based training as DMDRC members. Trainees actively participate in weekly interdepartmental seminars, minisymposia, journal clubs in specialized areas (endocrinology, cell signaling), and periodic scientific meetings where reports on original research are presented. The trainees (8 per year) will be principally medical (M.D.) or Ph.D. graduates who demonstrate a keen interest in taking advantage of these opportunities. Emphasis is placed on the vigorous recruitment of women and underrepresented minorities. Trainees are selected based upon their ability to conduct original research in a careful and critical manner, the nature and quality of their thesis and/or prior work, and recommendations by referees. Competitive applicants visit the campus and present a seminar. Facilities include modem laboratories (>300,000 n.s.f.) equipped for original research endeavors. Unique opportunities exist for advanced training in transgenic and KO siRNA mice, proteomics (MALDI and QToF mass spectrometry) & structural biology, 2-photon microscopy & imaging analysis, fcs, microarray, MRI/PET, etc.. The DMDRC T32 program sponsors bioethics training, career building, and planning. The DMDRC training program enjoys strong University-wide support.