The Biochemistry and Cell Biology of Metabolic Diseases

代谢疾病的生物化学和细胞生物学

• 批准号: 8293298
• 负责人: CRAIG C MALBON
• 金额: $ 35.17万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-14 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8293298
• 关键词: Biochemistry; Cellular biology; Metabolic Diseases

The institutional NRSA program sponsored by the Diabetes & Metabolic Diseases Research Center (DMDRC) offers multidisciplinary post-graduate training opportunities to the scientifically-trained (Ph.D.) and clinically-trained (M.D.) to acquire expertise in the study of metabolic diseases using state-of-the-art approaches of biochemistry, cell and molecular biology. Opportunities for training include diabetes & insulin action, protein metabolism, G-protein-coupled receptor action in disease states, cell signaling, Ras and MAP kinase regulation. Expertise is derived from 27 trainers from 9 departments with basic/clinical research in 6 major disciplines (physiology, pharmacology, biochemistry, molecular biology & cell biology, biomedical engineering). The training faculty support the tenet that a successful research career in the diverse and multifaceted area of endocrine and metabolic diseases requires a broadly-based background founded in these five major disciplines as well as a hybrid perspective which is receptive to strategies transcending the limits of one's immediate specialty. Training is principally as participants in vigorous, supportive research programs of individual trainers as well as more-broadly-based training as DMDRC members. Trainees actively participate in weekly interdepartmental seminars, minisymposia, journal clubs in specialized areas (endocrinology, cell signaling), and periodic scientific meetings where reports on original research are presented. The trainees (8 per year) will be principally medical (M.D.) or Ph.D. graduates who demonstrate a keen interest in taking advantage of these opportunities. Emphasis is placed on the vigorous recruitment of women and underrepresented minorities. Trainees are selected based upon their ability to conduct original research in a careful and critical manner, the nature and quality of their thesis and/or prior work, and recommendations by referees. Competitive applicants visit the campus and present a seminar. Facilities include modern laboratories (>300,000 n.s.f.) equipped for original research endeavors. Unique opportunities exist for advanced training in transgenic and KO siRNA mice, proteomics (MALDI and QToF mass spectrometry) & structural biology, 2-photon microscopy & imaging analysis, fcs,microarray, MRI/PET, etc.. The DMDRC T32 program sponsors bioethics training, career building, and planning. The DMDRC training program enjoys strong University-wide support.

由糖尿病和代谢疾病研究中心赞助的机构 NRSA 计划 （DMDRC）为受过科学训练的（博士）和 经过临床培训（医学博士），获得利用最先进技术研究代谢疾病的专业知识 生物化学、细胞和分子生物学的方法。培训机会包括糖尿病和胰岛素 作用、蛋白质代谢、疾病状态下的 G 蛋白偶联受体作用、细胞信号传导、Ras 和 MAP 激酶调节。来自 9 个部门的 27 名培训师拥有 6 个领域的基础/临床研究的专业知识 主要学科（生理学、药理学、生物化学、分子生物学与细胞生物学、生物医学 工程）。培训教师支持这样的宗旨：在多样化和多样化的领域中取得成功的研究生涯 内分泌和代谢疾病的多方面领域需要广泛的背景 这五个主要学科以及混合视角，可以接受超越现实的战略 一个人直接专业的限制。培训主要是作为积极、支持性研究的参与者 个人培训师计划以及 DMDRC 成员更广泛的培训。实习生 积极参加每周的部门间研讨会、小型研讨会、专业领域的期刊俱乐部 （内分泌学、细胞信号传导）以及定期的科学会议，其中报告原始研究 提出。受训者（每年 8 名）主要是医学博士（M.D.）或博士。表现出的毕业生 对利用这些机会的浓厚兴趣。重点是大力招聘 妇女和代表性不足的少数群体。根据学员的执行能力来选择学员 以仔细和批判的方式进行原创性研究，其论文和/或先前工作的性质和质量，以及 裁判员的建议。有竞争力的申请者参观校园并举办研讨会。设施 包括为原创研究工作配备的现代化实验室（>300,000 n.s.f.）。独特的机会 用于转基因和 KO siRNA 小鼠、蛋白质组学（MALDI 和 QToF 质量）的高级训练 光谱测定）和结构生物学、2 光子显微镜和成像分析、FCS、微阵列、MRI/PET 等。 DMDRC T32 计划赞助生物伦理学培训、职业建设和规划。 DMDRC 培训 该计划得到了大学范围内的大力支持。

项目成果

Rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Properties of phospho- and dephospho- forms and of two mutants in which Ser32 has been changed by site-directed mutagenesis.

• DOI: 10.1016/s0021-9258(18)42851-7
• 发表时间: 1992-03
• 期刊: The Journal of biological chemistry
• 作者: I. Kurland;M. El‐Maghrabi;J. Correia;S. Pilkis

Retinoic acid modulation of transmembrane signaling. Analysis in F9 teratocarcinoma cells.

视黄酸调节跨膜信号传导。

• 发表时间: 1990
• 期刊: The Journal of biological chemistry
• 作者: Galvin-Parton,PA;Watkins,DC;Malbon,CC
• 通讯作者: Malbon,CC

The effects of the plasminogen pathway on scar tissue formation.

纤溶酶原途径对疤痕组织形成的影响。

• DOI: 10.1097/00005537-200401000-00007
• 发表时间: 2004
• 期刊: The Laryngoscope.
• 作者: Samara,GhassanJ;Schaffner,AdamD;Eisenstat,Jonathan;Nguyen,Hoang-LanT
• 通讯作者: Nguyen,Hoang-LanT

Expression of the human apolipoprotein E gene suppresses steroidogenesis in mouse Y1 adrenal cells.

• DOI: 10.1073/pnas.88.6.2375
• 发表时间: 1991-03
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: M. Reyland;John T. Gwynne;Patricia Forgez;M. Prack;David L. Williams

Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin.

• DOI: 10.1186/s12964-016-0138-x
• 发表时间: 2016-08-02
• 期刊: Cell communication and signaling : CCS
• 作者: Gillis WQ;Kirmizitas A;Iwasaki Y;Ki DH;Wyrick JM;Thomsen GH
• 通讯作者: Thomsen GH