Patterns of Substance Use Among HIV Positive and Negative Aging MSM

HIV 阳性和阴性老年 MSM 的物质使用模式

• 批准号: 7686285
• 负责人: Jessica Griffin Burke
• 金额: $ 15.15万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7686285
• 关键词: Acquired Immunodeficiency Syndrome; Address; Age; Age Factors; Aging; Alcohol or Other Drugs use; Applications Grants; Attention; Characteristics; Cohort Studies; Data; Data Analyses; Development; Drug usage; Economics; Elderly; Exhibits; Funding; Future; Goals; HIV; HIV Seropositivity; Habits; Health; Heterosexuals; Intervention; Interview; Knowledge; Life Cycle Stages; Mediator of activation protein; Methods; Modeling; Outcome; Participant; Pattern; Population; Quality of life; Research; Research Project Grants; Secondary to; Social Problems; Substance abuse problem; Testing; Time; Unsafe Sex; Violence; base; cohort; cost effective; depression; design; experience; falls; innovation; men; men who have sex with men; middle age; prevent; research study; response; social

DESCRIPTION (provided by applicant): The goal of this research is to examine the patterns of substance use over time among an existing cohort of HIV positive and negative men who have sex with men (MSM) participating in the Multicenter AIDS Cohort Study (MACS). An important health issue that has received little research attention is how the patterns of substance use among MSM are carried from early age into later life and whether distinct patterns of substance use are associated with decreased functioning, increased health and social problems as MSM age. While research among heterosexual men has found a fall-off or decrease in drug use with increased age, existing research among MSM has not observed a substantial decline in drug use across the life course. This proposal seeks funding to conduct a mixed method study that includes 1) an innovative approach to secondary quantitative data analysis of existing MACS data and 2) qualitative in-depth interviews with select MACS participants. The analysis will compare trajectories of declining substance use with increasing or consistently high levels of use. These pattern comparisons will allow for the identification of resiliency characteristics associated with decreased substance use and related health and social problems. Results will be used as the basis of a future R21 grant application to develop and evaluate a model intervention to prevent substance abuse and related health and social problems among both HIV positive and negative MSM. Quantitative findings regarding the factors that contributed to decreased substance use over time and qualitative data regarding how the participants manage their substance use over time have direct implications for development of a strengths-based intervention. The analysis will also specifically seek to develop hypotheses from the qualitative and quantitative data that can be tested with other aging populations of substance users. Little is known regarding how substance use patterns change or stay stable as MSM age and the factors influencing patterns of change or stability in substance use across the life course. The results of this research will allow for the identification of resiliency characteristics associated with decreased substance use and related health and social problems and will be used as the basis for a future grant application to develop and evaluate a model intervention to prevent substance abuse and related health and social problems among both older HIV positive and negative MSM.

描述(申请人提供)：这项研究的目标是研究参与多中心艾滋病队列研究(MACS)的现有HIV阳性和阴性男男性接触者(MSM)随时间的药物使用模式。一个很少受到研究关注的重要健康问题是，MSM的物质使用模式是如何从早期带入晚年的，以及随着MSM年龄的增长，不同的物质使用模式是否与功能下降、健康和社会问题有关。虽然在异性恋男性中的研究发现，随着年龄的增长，药物使用量会下降或减少，但现有的MSM研究并没有观察到整个生命过程中药物使用量的大幅下降。这项建议寻求资金用于开展一项混合方法研究，其中包括1)对现有的互委会数据进行二次定量数据分析的创新方法，以及2)对选定的互委会参与者进行深入的定性访谈。这项分析将比较物质使用量下降的轨迹与使用量增加或持续高企的情况。这些模式比较将有助于确定与物质使用减少以及相关的健康和社会问题有关的复原力特征。结果将作为未来R21赠款申请的基础，以开发和评估一种模式干预措施，以预防HIV阳性和阴性MSM中的药物滥用和相关的健康和社会问题。关于导致药物使用量随时间减少的因素的定量结果，以及关于参与者如何随着时间的推移管理其药物使用量的定性数据，对基于强度的干预措施的发展具有直接影响。该分析还将特别寻求从定性和定量数据中开发假说，这些假说可以在其他老龄化的药物使用者群体中进行测试。关于物质使用模式如何随着MSM年龄的增长而变化或保持稳定，以及影响整个生命过程中物质使用模式变化或稳定的因素，我们知之甚少。这项研究的结果将有助于确定与减少药物使用和相关的健康和社会问题有关的复原力特征，并将作为未来赠款申请的基础，以开发和评估一种模式干预措施，以预防艾滋病毒阳性和阴性的老年MSM中的药物滥用和相关的健康和社会问题。