MaqFACS: Measuring expressive movement in monkeys

MaqFACS:测量猴子的表达运动

基本信息

  • 批准号:
    7554627
  • 负责人:
  • 金额:
    $ 9.36万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-01-09 至 2011-11-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): In developing animal models for understanding affective disorders of the face, including emotional expression deficits, various modes of facial paralysis, and specific speech disorders, researchers must describe the motor-component of the deficit. To date there is no methodology for quantifying these movement deficits in a monkey, not to mention a means with which these deficits may be compared to those that characterize neurological conditions in humans, such as Parkinson's disease, autism, depression or other affective disorders. Such a procedure, however, is critical, not only for documenting the severity of the deficit, but for quantifying resulting improvements after treatment. This project will develop a rigorous, objective and standardized tool for quantifying facial movement in the rhesus monkey, the species used most widely as a model for human biobehavioral, neurobiological, and affective disorders. This measurement tool is based directly on the human Facial Action Coding System (FACS), which is an anatomically-based system for quantifying facial movement according to the action of the underlying musculature. Therefore, we propose three specific aims to meet these goals. First, we will validate the location and organization of the facial musculature of the rhesus monkey using modern dissection techniques. Second, we will objectively qualify the facial appearance changes produced by stimulating each facial muscle in anesthetized monkeys using intramuscular electrical stimulation and then documenting the resulting facial movements. Third, once these basic components have been documented, we will establish a numerical system, using FACS criteria and terminology, to describe each individual component movement, i.e. a movement map, for the rhesus face. Finally, we will use existing video recordings of spontaneous behavior in rhesus to qualify the degree of intensity that is typical for each movement. These results will be packaged into a manual form, complete with photographic documentation of each movement at its varying levels of intensity for distribution to researchers in related areas of neuroscience and public health who work with animal models for clinical disorders. Not only with this system (MaqFACS) provide seminal data on the expressive facial repertoire of the rhesus monkey, benefiting those interested in natural ethology and communication, it will provide the standardization necessary for describing facial movement deficits, quantifying their degree of severity and range of improvement, in studies where monkeys are used as models for human affective and related disorders. Researchers using monkeys to model aspects of human affective and related disorders, including Parkinson's disease and depression, currently have no standardized method for quantifying deficits in facial movement, although such deficits are prominent in the phenotypes of many human disorders. This project aims to develop an anatomically- based system for measuring facial movement in the rhesus monkey, the main primate model for human affective disorders that is objective, standardized, and directly comparable to methods used for quantifying human facial movement in clinical studies (Ekman, Friesen & Hagar, 2002). The development of this system is critical for researchers to quantify the severity of facial movement deficits and evaluate improvements after clinical treatment. Ultimately, this system will advance our ability to model and treat human affective diseases.
描述(由申请人提供):在开发用于理解面部情感障碍的动物模型时,包括情感表达缺陷、各种面瘫模式和特定语言障碍,研究人员必须描述缺陷的运动成分。到目前为止,还没有一种方法来量化猴子的这些运动缺陷,更不用说将这些缺陷与人类神经系统疾病(如帕金森病、自闭症、抑郁症或其他情感障碍)的特征进行比较的方法。然而,这样的程序是至关重要的,不仅是为了记录缺陷的严重程度,而且是为了量化治疗后的改善。该项目将开发一种严格,客观和标准化的工具,用于量化恒河猴的面部运动,该物种最广泛地用作人类生物行为,神经生物学和情感障碍的模型。该测量工具直接基于人类面部动作编码系统(FACS),该系统是一种基于解剖学的系统,用于根据底层肌肉组织的动作量化面部运动。因此,我们提出三个具体目标来实现这些目标。首先,我们将使用现代解剖技术验证恒河猴面部肌肉组织的位置和组织。第二,我们将客观地鉴定通过使用肌内电刺激刺激麻醉猴的每一块面部肌肉产生的面部外观变化,然后记录由此产生的面部运动。第三,一旦这些基本组成部分已被记录,我们将建立一个数字系统,使用流式细胞仪的标准和术语,以描述每个单独的组件运动,即运动图,为恒河猴的脸。最后,我们将使用现有的恒河猴自发行为的视频记录来限定每个运动的典型强度。这些结果将被打包成一个手册的形式,完成每一个动作在其不同强度水平的摄影文件,分发给神经科学和公共卫生的相关领域的研究人员谁与动物模型的临床疾病。该系统(MaqFACS)不仅提供了有关恒河猴面部表情库的开创性数据,使那些对自然行为学和交流感兴趣的人受益,它还将提供描述面部运动缺陷所需的标准化,量化其严重程度和改善范围,在猴子用作人类情感和相关疾病模型的研究中。研究人员使用猴子来模拟人类情感和相关疾病的各个方面,包括帕金森病和抑郁症,目前还没有标准化的方法来量化面部运动的缺陷,尽管这种缺陷在许多人类疾病的表型中很突出。该项目旨在开发一种用于测量恒河猴面部运动的基于解剖学的系统,恒河猴是人类情感障碍的主要灵长类动物模型,其是客观的、标准化的,并且与临床研究中用于量化人类面部运动的方法直接可比(Ekman,弗里森& Hagar,2002)。该系统的开发对于研究人员量化面部运动缺陷的严重程度和评估临床治疗后的改善至关重要。最终,该系统将提高我们建模和治疗人类情感疾病的能力。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Of mice, monkeys, and men: physiological and morphological evidence for evolutionary divergence of function in mimetic musculature.
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LISA A. PARR其他文献

LISA A. PARR的其他文献

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{{ truncateString('LISA A. PARR', 18)}}的其他基金

The effect of Oxytocin on Social Perception and Social Reward
催产素对社会感知和社会奖励的影响
  • 批准号:
    8883719
  • 财政年份:
    2015
  • 资助金额:
    $ 9.36万
  • 项目类别:
Training in translational social neuroscience
转化社会神经科学培训
  • 批准号:
    8509788
  • 财政年份:
    2012
  • 资助金额:
    $ 9.36万
  • 项目类别:
Training in translational social neuroscience
转化社会神经科学培训
  • 批准号:
    8374072
  • 财政年份:
    2012
  • 资助金额:
    $ 9.36万
  • 项目类别:
Using MaqFACS to measure facial movement deficits in monkeys
使用 MaqFACS 测量猴子的面部运动缺陷
  • 批准号:
    8190085
  • 财政年份:
    2011
  • 资助金额:
    $ 9.36万
  • 项目类别:
MAQFACS: MEASURING FACIAL MOVEMENT IN RHESUS MONKEYS
MAQFACS:测量恒河猴的面部运动
  • 批准号:
    8357504
  • 财政年份:
    2011
  • 资助金额:
    $ 9.36万
  • 项目类别:
Using MaqFACS to measure facial movement deficits in monkeys
使用 MaqFACS 测量猴子的面部运动缺陷
  • 批准号:
    8317537
  • 财政年份:
    2011
  • 资助金额:
    $ 9.36万
  • 项目类别:
SOCIAL COGNITION AND EMOTIONAL AGING IN PRIMATES
灵长类动物的社会认知和情感衰老
  • 批准号:
    8357454
  • 财政年份:
    2011
  • 资助金额:
    $ 9.36万
  • 项目类别:
BEHAVIORAL AND NEURAL RESPONSES TO FACES AND EXPRESSIONS IN NONHUMAN PRIMATES
非人类灵长类动物对面部和表情的行为和神经反应
  • 批准号:
    8357505
  • 财政年份:
    2011
  • 资助金额:
    $ 9.36万
  • 项目类别:
MAQFACS: MEASURING FACIAL MOVEMENT IN RHESUS MONKEYS
MAQFACS:测量恒河猴的面部运动
  • 批准号:
    8357480
  • 财政年份:
    2011
  • 资助金额:
    $ 9.36万
  • 项目类别:
BEHAVIORAL, PHYSIOLOGICAL & NEUROANATOMICAL CONSEQUENCES OF REPETITIVE
行为、生理
  • 批准号:
    8172354
  • 财政年份:
    2010
  • 资助金额:
    $ 9.36万
  • 项目类别:

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