Clinical and Translational
Clinical and Translational
批准号:
7695952
负责人:
DANIEL D KARP
金额:
$21.42万
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-08-28 至 2013-06-30
关键词:
AccountingAdministratorAdoptionAdverse Drug Experience ReportAdverse Drug Reaction Reporting SystemsAntineoplastic AgentsAreaAwardBudgetsCancer CenterCancer Center Support GrantCare given by nursesCatalogingCatalogsCell FractionationChargeClinicClinicalClinical MedicineClinical ResearchClinical TrialsClinical and Translational Science AwardsCollaborationsCommunicationComplementComplexCorrelative StudyCytotoxic agentDailyData AnalysesDatabasesDevelopmentDoctor of PhilosophyDrug KineticsElectronic MailEpigenetic ProcessEquipment and supply inventoriesFeesFoundationsFreezingFundingFutureGiftsGrantGrowthHandwritingHealth SciencesHospitalsImmunologicsIndividualInfusion PumpsInfusion proceduresInstitutesInstitutionIntranetInvestmentsJust-in-time-conceptLaboratoriesMalignant NeoplasmsMedicalMedical RecordsMedicineMetabolicMononuclearNotificationNurse AdministratorNursing ServicesOnline SystemsOutpatientsPaperPathologyPatientsPeer ReviewPharmaceutical PreparationsPharmacodynamicsPharmacy facilityPhasePhase I Clinical TrialsPhysician ExecutivesPlayPoliciesPositioning AttributePreparationPrincipal InvestigatorProcessProteomicsProtocols documentationRNA analysisRecommendationRecruitment ActivityResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResidual stateResource SharingRoleSamplingSecureServicesSignal Transduction InhibitorSiteSourceSpecialistSpecimenSystemSystems AnalysisTimeTodayTranslational ResearchTreatment ProtocolsUnited States National Institutes of HealthUniversity of Texas M D Anderson Cancer CenterUpdateUrineVaccinesVenous blood samplingVirginiaVisitanticancer researchaustinbasecancer preventioncomputerizedcostdata managementdensitydigitaldrug developmentfootimprovedinhibitor/antagonistinnovationmembermulticatalytic endopeptidase complexpatient orientedprogramssmall moleculetreatment center
中文摘要
自1990年成立以来,临床与转化研究中心(CTRC)一直是主要的临床与转化研究中心
英文摘要
Since its inception in 1990, the Clinical & Translational Research Center (CTRC) has served as the primary
site for patient-oriented, protocol-based, innovative clinical and translational research. Key phase I and II
studies have contributed to the development of 18 new FDA-approved cancer drugs since 2002. Highest
priority is given to studies that seek to answer biologically-based research questions. NIH peer-reviewed
studies have comprised >15% of CTRC activity and > 37% of patient registrations since 2002. The total
CTRC annual budget has increased to $3.5 million (20.5 clinical FTEs and 33.6 lab FTEs). The laboratory
budget is $1.8M of this total, and only 14% ($254K) of the lab budget is requested in this proposal. The
CTRC provides outstanding nursing care, full phlebotomy/lab services for pharmacokinetic (PK) and
pharmacodynamic (PD) studies, as well as rigorous research infrastructure and oversight. Core grant
funding is leveraged more than 2:1 to support correlative studies that could not be conducted otherwise. In
the last 5 years, 7,750 patient registrations recorded on over 450 protocols, representing usage by 96
investigators from 16 programs. In 2007 alone, there have been 15,099 patient visits and >12,000 PK/PD
timepoints. The CTRC uses a broad array of targeted small molecules, immunologic agents, signal
transduction inhibitors, epigenetic modulators, vaccines, and proteosome inhibitors. Classic cytotoxic agents
comprise less than 1/3 of all drug studies. The unit received a highly-favorable review in 2003 with the
explicit recommendation to strengthen charge capture for billable services. Since that time, we have
instituted a robust accounting and billing system that now contributes over $500,000 (28%) to the total
budget. A medical director and nurse manager supervise daily activities and a 20-member oversight
committee directs development and prioritization of studies. A recently-recruited PhD Laboratory Manager
will provide oversight of our increasingly-complex phase I studies. New services include: a computerized
cataloging system for frozen specimens; specialized preparation for proteomics, DMA, RNA analysis, and
mononuclear cell fractionation; real-time Principal Investigator email notification of sample shipments; 24-hr
phlebotomy coverage; and a secure "just-in-time" inventory system for protocol-specific PK and PD kits.
Future plans include: re-organization of the Lab Service into 4 teams to improve communication with the
individual Cancer Center programs, and expansion of lab space to accommodate 30% annual growth;
development of a comprehensive web-based Oracle application to replace paper and handwritten systems.
In February 2007, the CTRC attracted a $1.5M gift to develop a computerized Advanced Research
Management and Data Analysis system (the ARMADA project), leveraging further the value of NIH's
investment. Funds requested will support the critical phlebotomy and laboratory services needed to execute
today's highly-complex translational cancer drug development.
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会议论文
Center for Clinical and Translational Sciences (CCTS)
-
批准号:10316843
-
项目类别:
-
资助金额:$185.96万
-
财政年份:2021
-
负责人:DANIEL D KARP
-
依托单位:
Center for Clinical and Translational Sciences (CCTS)
-
批准号:10295669
-
项目类别:
-
资助金额:$7.15万
-
财政年份:2021
-
负责人:DANIEL D KARP
-
依托单位:
Center for Clinical and Translational Sciences (CCTS)
-
批准号:10217650
-
项目类别:
-
资助金额:$40.62万
-
财政年份:2020
-
负责人:DANIEL D KARP
-
依托单位:
Center for Clinical and Translational Sciences (CCTS)
-
批准号:10654064
-
项目类别:
-
资助金额:$290.31万
-
财政年份:2019
-
负责人:DANIEL D KARP
-
依托单位:
Center for Clinical and Translational Sciences (CCTS)
-
批准号:10655023
-
项目类别:
-
资助金额:$7.15万
-
财政年份:2019
-
负责人:DANIEL D KARP
-
依托单位:
Convalescent Plasma to Limit Coronavirus Associated Complications
-
批准号:10224557
-
项目类别:
-
资助金额:$984.32万
-
财政年份:2019
-
负责人:DANIEL D KARP
-
依托单位:
Center for Clinical and Translational Sciences (CCTS)
-
批准号:9983233
-
项目类别:
-
资助金额:$562.2万
-
财政年份:2019
-
负责人:DANIEL D KARP
-
依托单位:
Center for Clinical and Translational Sciences (CCTS)
-
批准号:10707570
-
项目类别:
-
资助金额:$7.15万
-
财政年份:2019
-
负责人:DANIEL D KARP
-
依托单位:
Center for Clinical and Translational Sciences (CCTS)
-
批准号:10215640
-
项目类别:
-
资助金额:$575.06万
-
财政年份:2019
-
负责人:DANIEL D KARP
-
依托单位:
Center for Clinical and Translational Sciences (CCTS)
-
批准号:10441621
-
项目类别:
-
资助金额:$562.56万
-
财政年份:2019
-
负责人:DANIEL D KARP
-
依托单位:
EASTERN COOPERATIVE ONCOLOGY GROUP
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批准号:2821778
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项目类别:
-
资助金额:$14.65万
-
财政年份:1999
-
负责人:DANIEL D KARP
-
依托单位:
EASTERN COOPERATIVE ONCOLOGY GROUP
-
批准号:6173835
-
项目类别:
-
资助金额:$14.98万
-
财政年份:1999
-
负责人:DANIEL D KARP
-
依托单位:
EASTERN COOPERATIVE ONCOLOGY GROUP
-
批准号:6377050
-
项目类别:
-
资助金额:$13.84万
-
财政年份:1999
-
负责人:DANIEL D KARP
-
依托单位:
PRIMARY BREAST CANCER THERAPY GROUP-NSABP
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批准号:3558508
-
项目类别:
-
资助金额:$6.24万
-
财政年份:1987
-
负责人:DANIEL D KARP
-
依托单位:
EASTERN COOPERATIVE ONCOLOGY GROUP
-
批准号:2084567
-
项目类别:
-
资助金额:$33.44万
-
财政年份:1982
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负责人:DANIEL D KARP
-
依托单位:
EASTERN COOPERATIVE ONCOLOGY GROUP
-
批准号:3555878
-
项目类别:
-
资助金额:$29.27万
-
财政年份:1982
-
负责人:DANIEL D KARP
-
依托单位:
EASTERN COOPERATIVE ONCOLOGY GROUP
-
批准号:3555876
-
项目类别:
-
资助金额:$25.25万
-
财政年份:1982
-
负责人:DANIEL D KARP
-
依托单位:
EASTERN COOPERATIVE ONCOLOGY GROUP
-
批准号:2084568
-
项目类别:
-
资助金额:$35.81万
-
财政年份:1982
-
负责人:DANIEL D KARP
-
依托单位:
ONCOLOGY
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批准号:3555871
-
项目类别:
-
资助金额:$4.53万
-
财政年份:1982
-
负责人:DANIEL D KARP
-
依托单位:
EASTERN COOPERATIVE ONCOLOGY GROUP
-
批准号:3555877
-
项目类别:
-
资助金额:$31.32万
-
财政年份:1982
-
负责人:DANIEL D KARP
-
依托单位:
海外基金