Cabohydrate Synthetic Chemistry

碳水化合物合成化学

• 批准号: 7534125
• 负责人: PETER H SEEBERGER
• 金额: $ 20.2万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7534125
• 关键词: Adhesions; Agonist; Binding; Biological Assay; CCL21 gene; Carbohydrates; Cell surface; Denmark; Development; Employment; Faculty; Funding; Galactose; Glycopeptides; Goals; Heparin; Heparitin Sulfate; Homing; Inorganic Sulfates; Institutes; Knock-out; L-Selectin; Laboratories; Libraries; Ligands; Lymphocyte; Numbers; Oligosaccharides; Paper; Participant; Peripheral; Polysaccharides; Positioning Attribute; Preparation; Process; Productivity; Program Research Project Grants; Publications; Publishing; Research Project Grants; Resources; Rest; Role; Scientist; Side; Specificity; Staging; Switzerland; Synthesis Chemistry; Travel; Unspecified or Sulfate Ion Sulfates; Work; carbohydrate binding protein; lymph nodes; member; novel; programs; sialyl-2-3-(6' -sulfo)galactosyl-1-4-(fucopyranosyl-1-3)-N-acetylglucosamine; sulfation

Core A will synthesize oligosaccharides derivatives, which are critical for the research projects I, II, and III. The Core is an important part of this program project in that it will provide invaluable oligosaccharides and glycopeptides to determine ligand specificity of carbohydrate-binding proteins and the roles of cell surface oligosaccharides in adhesion. In addition, the Core will provide carbohydrate rhicroarray including heparan sulfate oligosaccharide array for assaying carbohydrate-binding proteins.

核心A将合成低聚糖衍生物，这对研究项目I、II和 核心是这一方案项目的重要组成部分，因为它将提供无价的寡糖 和糖肽确定碳水化合物结合蛋白的配基特异性和细胞的作用 表面低聚糖的粘附性。此外，Core还将提供碳水化合物微芯片 包括用于检测碳水化合物结合蛋白的硫酸乙酰肝素低聚糖阵列。