P-4: Targeting EGFR and the IGF Axis for Therapy of Head and Neck Squamous Cell

P-4：靶向 EGFR 和 IGF 轴治疗头颈鳞状细胞

• 批准号: 7515783
• 负责人: HO-YOUNG LEE
• 金额: $ 21.15万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7515783
• 关键词: Area; Biological; Cancer Biology; Clinical; Clinical Research; Commit; Communication; Data; Development; Diagnosis; Disease; Doctor of Medicine; Doctor of Philosophy; Epidermal Growth Factor Receptor; Evaluation; Faculty; Foundations; Funding; Future; Gene Expression Profiling; Genes; Goals; Head; Head and Neck Cancer; Head and Neck Surgery; Head and neck structure; Human; Laboratories; Lesion; Medical Oncologist; Mentors; Methods; Molecular; Molecular and Cellular Biology; Oligonucleotide Microarrays; Operative Surgical Procedures; Oral; Patients; Physicians; Postdoctoral Fellow; Premalignant; Prevention; Process; Program Description; Program Development; Protocols documentation; Radiation; Radiation Oncology; Recruitment Activity; Reproduction spores; Research; Research Personnel; Research Project Grants; Risk Assessment; Scientist; Senior Scientist; Somatomedins; Specimen; Squamous Cell; Training; Translating; Translational Research; University of Texas M D Anderson Cancer Center; Woman; Work; base; cancer risk; career; design; experience; innovation; interest; professor; programs; response; success

The Career Development Program is designed to provide training and guidance for academic physicianscientists, clinician-investigators and laboratory-based scientists who wish to dedicate their efforts to translational research in the area of diagnosis, prevention and treatment of head and neck cancer. In order to meet this goal, the Career Development Program has developed these specific objectives: 1) To recruit and train physicians, scientists and senior postdoctoral fellows to become outstanding translational investigators in the field of head and neck cancer; 2) To educate awardees in the basic principles of cancer biology, at both the molecular and cellular level, with an emphasis on translational science; 3) To provide a firm foundation for awardees in the specific area of head and neck cancer biology, laboratory, clinical and epidemiologic evaluation; and 4) To guide awardees through the development process of becoming effective head and neck cancer translational researchers. Since its inception in 2002, the Career Development Program (CDP) has funded 11 Career Development recipients, including the following: Erich M. Sturgis, M.D.; Edward S. Kim, M.D.; Christopher J. Barnes, Ph.D.; Abhijit Mazumdar, Ph.D.; AnneTsao, M.D.; F. Christopher Holsinger, M.D.; Ho-Young Lee, Ph.D., David L. Schwartz, M.D.; Naijie Jing, M.D.; and Michael Kupferman, M.D; and, most recently, Seetharaman Balasenthil, Ph.D. Dr. Ho-Young Lee serves as an excellent example of the early success of this program, as reflected by her contributions to this HN SPORE renewal application in the development of a major research project proposed in this application, Project 4 (Project Co-Leaders, Bonnie S. Glisson, M.D., and Ho-Young Lee, PhD) In response to concerns raised in our previous review, we are pleased to note that Dr. Jeffrey N. Myers (Professor and Chair, Department of Head and Neck Surgery) and Dr. Kie-Kian Ang (Professor and Head of Head and Neck Radiation Oncology, Department of Radiation Oncology) have enthusiastically agreed to co-lead this important program, bringing outstanding translational research and mentoring experience. We are also pleased to note the inclusion of Dr Elizabeth Travis, Associate Director, Women Faculty Programs, MDACC, as a new internal advisor for the career development and promotion of women faculty in this program.

职业发展计划旨在为学术物理学家和科学家提供培训和指导， 临床研究人员和实验室科学家，他们希望致力于 头颈部癌症的诊断、预防和治疗领域的转化研究。为了 为了实现这一目标，职业发展计划制定了以下具体目标：1）招募 培养医生、科学家和高级博士后成为杰出的翻译家， 2）教育获奖者了解癌症的基本原理 生物学，在分子和细胞水平上，重点是转化科学; 3）提供一个 为头颈癌生物学、实验室、临床和医学领域的获奖者奠定坚实的基础。 流行病学评估;以及4）指导获奖者通过发展过程变得有效 头颈癌转化研究人员。自2002年成立以来，职业发展 项目（CDP）资助了11名职业发展接受者，包括：斯特吉斯， 医学博士; Edward S. Kim，医学博士; Christopher J.巴恩斯，博士; Abhijit Mazumdar，博士; AnneTsao，医学博士; F. Christopher Holsinger，医学博士; Ho-Young Lee，博士，大卫湖施瓦茨，医学博士; Naijie Jing，医学博士;和迈克尔 Kupferman，M. D;以及最近的Seetharaman Balasenthil，Ph.D. Ho-Young Lee博士担任 这是该计划早期成功的一个很好的例子，她对HN SPORE的贡献反映了这一点 续期申请中提出的一项重大研究项目的开发申请，即项目4 （项目联合领导人，邦妮S。格利森，医学博士，和Ho-Young Lee博士） 我们以前的审查，我们很高兴地注意到，博士杰弗里N。迈尔斯（教授和椅子，系 头颈外科）和Kie-Kian Ang博士（头颈放射肿瘤学教授和负责人， 放射肿瘤学系）热情地同意共同领导这一重要计划， 杰出的翻译研究和指导经验。我们还高兴地注意到， 伊丽莎白特拉维斯博士，副主任，妇女教师计划，MDACC，作为一个新的内部顾问， 在该方案中促进女教员的职业发展和晋升。