TRANSFORMATIVE APPROACH TO REDUCE RESEARCH DISPARITIES TOWARDS DRUG USERS

描述（由申请人提供）：虽然个别研究人员和项目的重点是代表性不足的人口和急需服务的人口，吸毒者仍然被排除在研究之外，与服务无关。这项拟议的研究将通过现有的社区研究中心改变研究格局，该中心是华盛顿大学CTSA的一个关键组成部分。在这个新的NIDA计划中，我们将扩展我们成功的NIDA模式，积极招募和招收多代代表性不足的人群，特别是吸毒者，参加研究，并将他们与迫切需要的健康和社会服务联系起来。 与华盛顿大学CTSA的多个核心合作，该项目将招募，登记和跟进参与者，以实现这些具体目标：1。在研究者、协调员、IRB成员和人类研究保护办公室（HRPO）工作人员中进行需求评估，以了解在研究中排除、招募和保留代表性不足的人群（包括吸毒者）的态度; 2.）评估需求评估的结果，以制定教育指导方针和建议，使研究更具包容性。3a.）将我们的CTSA基于街道的外展模式扩展到针对最近使用非法药物的人，并将他们与CCBR联系起来，在那里他们将被转介到卫生服务部门，评估病史和精神病史，并邀请参加华盛顿大学医学院（WUSM）的研究; 3b.）将200名符合研究条件的受试者随机分配到新建立的CCBR导航器模型（转介到相关WUSM研究）或增强的导航模型（“研究大使”指导受试者完成所有研究阶段）。将在随机化后30天、2个月和3个月评估有效性; 3c.）评估该模型的有效性，将参与者转诊到初级保健院和其他所需的服务，提高对导航的满意度，减少感知到的歧视，并报告参与障碍较少。 这笔赠款将提供机会，进一步翻译和传播基于证据的做法，在所有领域的公共卫生吸毒者。 公共卫生相关性：该项目将通过开发、使用和评估创新方法，招募和登记多代代表性不足的人群，包括吸毒者，参加相关的研究，从而提高医学研究的普遍性，从而加强公共卫生。这些以社区为基础的研究服务将减少研究人员认为难以招募和留住代表性不足的人群的看法，为修订严格的纳入/排除标准提供催化剂，以纳入这些代表性不足的人群，并将参与者与以前无法获得的关键服务联系起来。

DESCRIPTION (provided by applicant): Although individual researchers and projects have focused on underrepresented populations and populations critically in need of services, drug users remain excluded from research studies and unlinked to services. This proposed study will change the research landscape through the existing Center for Community Based Research, a pivotal component of the Washington University CTSA. In this new NIDA initiative, we will extend our successful NIDA model to actively recruit and enroll multi-generational underrepresented populations, specifically drug users, into research studies and will link them to desperately needed health and social services. Working with the multiple cores of the Washington University CTSA, this project will recruit, enroll and follow up participants to achieve these specific aims: 1.) Conduct a Needs Assessments among investigators, coordinators, IRB members and Human Research Protection Office (HRPO) staff to understand attitudes toward excluding, enrolling and retaining underrepresented populations, including drug users, in research; 2.) Evaluate the findings from the Needs Assessment to formulate educational guidelines and recommendations to make research more inclusive. 3a.) Extend our CTSA street-based outreach model to target persons with recent illicit drug use and link them to the CCBR, where they will be referred to health services, assessed for medical and psychiatric history, and invited to participate in Washington University School of Medicine (WUSM) research studies; 3b.) Randomize 200 study-eligible participants to either the newly established CCBR navigator model of referral to a relevant WUSM study, or to an enhanced navigation model where a "study ambassador" guides the participant through all research stages. Effectiveness will be assessed at 30 days, 2 months and 3 months after randomization; 3c.) Evaluate the effectiveness of the model to refer participants to primary care homes and other needed services, to increase satisfaction with navigation, to reduce perceived discrimination, and to report fewer barriers to participation. This grant will provide the opportunity to further translate and disseminate evidence- based practices across all arenas of public health for drug users. PUBLIC HEALTH RELEVANCE: This project will enhance public health by increasing the generalizability of medical research studies by developing, using and evaluating innovative methods to recruit and enroll multi- generational underrepresented populations, including drug users, into relevant research studies. These community-based research services will reduce researchers' perceptions that enrolling and retaining underrepresented populations is difficult, provide a catalyst to revise stringent inclusion/exclusion criteria to include these underrepresented populations, and link participants with critical and previously unattainable services.