BINDONG LIU, PHD, LAB STARTUP PACKAGE: HIV IN AFRICAN AMERICANS

BINDONG LIU，博士，实验室启动计划：非洲裔美国人中的艾滋病毒

• 批准号: 7724718
• 负责人: Bindong Liu
• 金额: $ 19.6万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724718
• 关键词: Acquired Immunodeficiency Syndrome; Affect; African American; Alleles; Anti-Retroviral Agents; CD4 Positive T Lymphocytes; Codon Nucleotides; Computer Retrieval of Information on Scientific Projects Database; Condition; Cytidine Deaminase; DNA; Defect; Disease Progression; Exons; Funding; Genetic Variation; Grant; HIV; HIV-1; In Vitro; Institution; Nuclear Import; Population; Prevention; Protein Family; Race; Rate; Reporting; Research; Research Personnel; Resources; Source; Therapeutic; Time; United States National Institutes of Health; Variant; Viral Reverse Transcription; apolipoprotein B mRNA editing enzyme; ethnic minority population; improved; interest; polypeptide; racial and ethnic; transmission process; viral DNA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G (Apobec3G) is a newly defined host anti-retroviral factor. It belongs to a family of proteins that have cytidine deaminase activity. It is commonly believed that Apobec 3G restricts HIV-1 replication by inducing lethal G to A hypermutations in the newly synthesized viral DNA. It has also been observed that Apobec3G causes viral reverse transcription (RT), DNA nuclear import and integration of multiple steps of defects during HIV-1 replication. There are still some major gaps between the hypermutations and the multiple steps of defects. One of our research interest is to understand the details of how Apobec 3G restricts HIV-1 replication. More and more in vitro evidence suggested that Apobec 3G is a potent host restriction factor against HIV-1 replication. It is still uncertain whether Apobec 3G also influence HIV transmission and disease progression. It has been reported that HIV and AIDS disproportionately affect African Americans at a rate that is 10 times greater than is found in the U.S. White population. Since 1996, more AIDS cases have occurred among African Americans than any other U.S racial/ethnic population. A recent study reported that one codon-changing variant, H186R in exon 4 of Apobec 3G, was polymorphic in African Americans. For African Americans, the variant allele 186R was strongly associated with decline in CD4 T cells, the 186R allele was also associated with accelerated progression to AIDS-defining conditions in African Americans. It would be interesting to know whether the variation of Apobec 3G will influence HIV transmission and disease progression. We will be interested to look at the relationship between the variation of Apobec 3G and HIV transmission and disease progression among different racial group through the study of Apobec 3G genetic variation and expression levels. It will assist in determining how to improve or develop new prevention or therapeutic approaches specific to ethnic minority populations.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 载脂蛋白B mRNA编辑酶催化多肽样3G（APOBEC3G）是新定义的宿主抗逆转录病毒因子。它属于具有胞苷脱氨酶活性的蛋白质家族。通常认为，APOBEC 3G通过将致命的G诱导到新合成的病毒DNA中的过度过度来限制HIV-1复制。还观察到，APOBEC3G引起病毒逆转录（RT），DNA核进口和HIV-1复制过程中多个缺陷步骤的整合。在过度渗透和缺陷的多个步骤之间仍然存在一些主要差距。我们的研究兴趣之一是了解APOBEC 3G如何限制HIV-1复制的细节。 越来越多的体外证据表明，APOBEC 3G是针对HIV-1复制的有效宿主限制因素。 APOBEC 3G仍然不确定是否也影响HIV传播和疾病进展。据报道，艾滋病毒和艾滋病对非裔美国人的影响不成比例，比美国白人人口高10倍。自1996年以来，非裔美国人中发生的艾滋病案件比其他任何美国种族/族裔人口都多。最近的一项研究报道，在非裔美国人中，APOBEC 3G外显子4中的一种改变密码子的变体H186R是多态性的。对于非洲裔美国人来说，186R的变体等位基因与CD4 T细胞的下降密切相关，186R等位基因也与加速到定义非洲裔美国人的艾滋病状况的进展有关。知道APOBEC 3G的变化是否会影响HIV传播和疾病进展会很有趣。通过研究APOBEC 3G遗传变异和表达水平，我们将有兴趣研究不同种族群体中APOBEC 3G的变异与HIV传播与疾病进展之间的关系。它将有助于确定如何改善或开发针对少数民族人群的新预防或治疗方法。