Molecular dissection of allergen sensitisation and immunotherapy: direct application to precision medicine in treatment of asthma

哮喘是一种主要的全球健康负担，具有巨大的社会经济影响。大多数哮喘患者是过敏性的。过敏原免疫疗法是改变自然病程的唯一治疗方法，但在许多接受治疗的患者中不起作用，并且缺乏用于患者选择和治疗成功的免疫监测的稳健的实验室生物标志物。因此，过敏原免疫疗法不提供给大多数患者，然后无限期地依赖药物治疗。这项研究将满足这些需求。

Asthma is a major global health burden with huge socioeconomic impact. Most asthmatic patients are allergic. Allergen immunotherapy is the only treatment to alter the natural disease course, but does not work in many treated patients, and robust laboratory biomarkers for patient selection and immune monitoring of treatment success are lacking. Therefore, allergen immunotherapy is not offered to most patients who then rely on medications indefinitely. This research will address these needs.