Biostatistics and Bioinformatics

生物统计学和生物信息学

• 批准号: 7786026
• 负责人: JOHN A BARNARD
• 金额: $ 31.86万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7786026
• 关键词: Biochemical Markers; Bioinformatics; Biological Markers; Biometry; Case-Control Studies; Classification; Clinical; Coronary Arteriosclerosis; DNA Sequencing Facility; Data; Data Collection; Databases; Ensure; Family; Genotype; Guidelines; Haplotypes; Informatics; Logistic Regressions; Maps; Microarray Analysis; Modeling; Molecular; Quantitative Trait Loci; Regression Analysis; Safety; Sample Size; Single Nucleotide Polymorphism; Source; Statistical Methods; Testing; Trees; United States National Institutes of Health; Validation; base; case control; data management; data sharing; design; genetic linkage analysis; repository; statistics

This Core will provide integral support for the design, data management, analysis, and interpretation for each of the four projects. Specifically, the Core analysis activities will include 1) model-based (parametric) and model-free (nonparametric) linkage analysis; 2) family-based and case-control association testing for fine mapping; 3) quantitative trait loci (QTL) analysis and expression QTL analysis; 4) microarray analysis; and 5) model building and validation for prediction. In addition, the Core will interact with the Genotyping and Sequencing Core C and Clinical Core D, and the Projects to ensure the quality, reliability, safety, and availability of the relevant data and results. The Core will provide computational and informatics expertise and facilities to the Projects and other Cores.

该核心将为四个项目中的每一个项目的设计、数据管理、分析和解释提供整体支持。具体而言，核心分析活动将包括1）基于模型（参数）和无模型（非参数）的连锁分析; 2）用于精细作图的基于家系和病例对照关联检验; 3）数量性状基因座（QTL）分析和表达QTL分析; 4）微阵列分析; 5）预测模型构建和验证。此外，核心将与基因分型和测序核心C和临床核心D以及项目互动，以确保相关数据和结果的质量、可靠性、安全性和可用性。核心将提供计算和信息学专业知识 项目和其他核心的设施。