NICHD Institutional Training for Pediatricians (T32)

描述（由申请人提供）：该机构NRSA的长期目标是培养新一代的转化和实验室研究儿科专科医生。培训经验的重点将是分子和转化医学，定义为使用复杂的分子方法来改善儿科疾病的诊断和治疗。该项目位于全国儿童医院的校园内，全国儿童医院研究所和俄亥俄州立大学医学院儿科系的学术基地。近年来，我们的机构在研究方面投入了大量资源。该研究所以独特的方式组织为重点中心，有目的地消除传统的基于学术划分的研究孤岛，并根据科学兴趣和需求为研究人员和学员提供对齐。这种独特的组织模式允许儿科部门采用本文所述的亚专科研究培训的新方法。简而言之，每个中心都将作为研究员的培训单位和科学共同体发挥作用。个别研究员的科学训练和指导将由选定的训练单位（中心）及其教员负责，除了指定教员导师的传统模式之外。利用这种独特的模式，我们在前5年获得了巨大的成功。我们建议续签该NRSA，并计划在下一个奖励期共培养8名医学博士或医学博士/博士儿科科学家。一群才华横溢的高级医学博士和博士科学家热情地同意担任项目教员。我们独特的培训模式，加上建立一流研究基础设施的组织承诺，使全国儿童医院处于有利地位，可以提供最高水平的亚专科研究培训计划。

DESCRIPTION (provided by applicant): The long-term objective of this Institutional NRSA is to train a new generation of pediatric subspecialists in translational and laboratory research. The focus of the training experience will be molecular and translational medicine, defined as the use of sophisticated molecular approaches to improve diagnosis and treatment of pediatric diseases. The program is physically located on the campus of Nationwide Children's Hospital, the academic home of both The Research Institute at Nationwide Children's Hospital and the Department of Pediatrics in the College of Medicine at The Ohio State University. In recent years, there has been a substantial resource commitment to research at our institution. The Research Institute is uniquely organized into Centers of Emphasis, which purposefully dissolve the traditional academic division-based silos of research and provide for alignment of investigators and trainees based on scientific interests and needs. This unique organizational model allows the Department of Pediatrics to adopt the novel approach to subspecialty research training described herein. In brief, each of the Centers will function as a training unit and scientific community for fellows. The scientific training and mentoring for individual fellows will be the responsibility of the selected training unit (Center) and its faculty, in addition to the traditional model of a named faculty mentor. Using this unique model, we were highly successful in the first 5 years of funding. We propose to renew this NRSA and plan to train a total of 8 MD or MD/PhD pediatric scientists over the next award period. A talented cadre of senior M.D. and Ph.D. scientists have enthusiastically agreed to serve as Program Faculty. Our unique training model, combined with the organizational commitment to build a first-rate research infrastructure, places Nationwide Children's Hospital in a favorable position to offer the highest caliber subspecialty research training program possible. PUBLIC HEALTH RELEVANCE: Recent advances in biomedical research have created an extraordinary opportunity for advancement in prevention and treatment of diseases of childhood by molecular approaches. A major obstacle is the lack of a well-trained workforce of pediatric physician scientists. This training grant is designed to aggressively train a cadre of outstanding pediatric scientists to meet this critical need for new talent.