Analysis of the Data from Vision in Preschoolers (VIP) Study

学龄前儿童视力 (VIP) 研究数据分析

• 批准号: 7740396
• 负责人: Gui-shuang Ying
• 金额: $ 19.89万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7740396
• 关键词: Address; Age; Amblyopia; Anisometropia; Astigmatism; Bilateral; Blindness; Caring; Characteristics; Child; Childhood; Clinical; Data; Data Analyses; Data Set; Databases; Disabled Persons; Disease; Early Diagnosis; Ethnic group; Eye; Goals; Head Start Program; Hyperopia; Lead; Monocular Vision; Myopia; National Eye Institute; Nursery Schools; Nurses; Phase; Preschool Child; Prevalence; Procedures; Productivity; Public Health; Publishing; Receiver Operating Characteristics; Refractive Errors; Relative (related person); Resources; Retinoscopy; Sample Size; Screening procedure; Severities; Strabismus; Testing; Vision; Vision Disorders; Vision Screening; experience; group support; handicapping condition; meetings; prevent; tool; user-friendly; web site

DESCRIPTION (provided by applicant): The proposed project will utilize the comprehensive dataset from the Vision in Preschoolers (VIP) Study, a multi-center, cross-sectional, two-phased study sponsored by the National Eye Institute, to address unanswered questions that are of clinical and public health importance in vision screening. The specific aims of this proposal do not include the major goals of the VIP Study, which were already accomplished and published. Instead, the proposed project involves the additional analysis of the VIP data to address the following important new aims, some of which were raised by experts during the National Eye Institute-sponsored Expert Panel Meeting in July 2005: (1) Evaluate the validity of noncycloplegic retinoscopy, Retinomax Autorefractor, SureSight Vision Screener, and Lea Symbols VA test for detecting VIP-defined hierarchical Group 1 conditions only (most severe), Group 1 & 2 conditions (most and moderately severe), all VIP-targeted vision conditions, and for detecting each specific type of refractive error (myopia, hyperopia, astigmatism, and anisometropia) with various levels of severity, by using receiver operating characteristic (ROC) analysis. Make ROC results available to the public through an interactive, user- friendly website. (2) Examine the relation between anisometropia and unilateral amblyopia and between bilateral high refractive error and bilateral amblyopia, and the differences in their relation as a function of age of the child. (3) Determine the ethnic-specific prevalence of VIP-targeted vision conditions among Head Start preschool children. The VIP dataset is a unique resource to evaluate the operating characteristics of the best-performing vision screening tools that are now being used widely by organizations that conduct preschool vision screening, and to better understand vision conditions among preschoolers. The very large sample size (N=4,040), as well as the experience and high productivity of the VIP Study Group, support the feasibility and likelihood of high yield of the proposed project.

描述（由申请人提供）：拟议的项目将利用来自学龄前儿童（VIP）视力研究的综合数据集，这是一项由国家眼科研究所赞助的多中心，横断面，两阶段研究，以解决视力筛查中具有临床和公共卫生重要性的未回答问题。这项建议的具体目标不包括已经完成并公布的《要人研究》的主要目标。相反，拟议的项目涉及对VIP数据的额外分析，以解决以下重要的新目标，其中一些是专家在2005年7月国家眼科研究所主办的专家小组会议上提出的：（1）评价非散瞳视网膜检影、Retinomax自动验光仪、SureSight视力筛查仪的有效性，和莱亚Symbols VA测试，仅用于检测VIP定义的分层第1组条件（最严重），第1组和第2组条件（大多数和中度严重），所有VIP目标视力状况，并用于检测每种特定类型的屈光不正通过使用受试者工作特征（ROC）分析，对具有不同严重程度的近视、远视、散光和屈光参差进行评估。通过一个互动的、用户友好的网站向公众提供ROC结果。(2)检查屈光参差和单侧弱视之间的关系，以及双侧高度屈光不正和双侧弱视之间的关系，以及儿童年龄对其关系的影响。(3)确定种族特定的患病率VIP为目标的视力状况中的头开始学龄前儿童。VIP数据集是一个独特的资源，用于评估目前被进行学龄前视力筛查的组织广泛使用的最佳视力筛查工具的操作特征，并更好地了解学龄前儿童的视力状况。非常大的样本量（N = 4，040）以及VIP研究组的经验和高生产率支持拟议项目的可行性和高产率的可能性。