Analysis of the Data from Vision in Preschoolers (VIP) Study

学龄前儿童视力 (VIP) 研究数据分析

• 批准号: 7892462
• 负责人: Gui-shuang Ying
• 金额: $ 19.8万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7892462
• 关键词: Address; Age; Amblyopia; Anisometropia; Astigmatism; Bilateral; Blindness; Caring; Characteristics; Child; Childhood; Clinical; Data; Data Analyses; Data Set; Databases; Disabled Persons; Disease; Early Diagnosis; Ethnic group; Eye; Goals; Head Start Program; Hyperopia; Lead; Monocular Vision; Myopia; National Eye Institute; Nursery Schools; Nurses; Phase; Preschool Child; Prevalence; Procedures; Productivity; Public Health; Publishing; Receiver Operating Characteristics; Refractive Errors; Relative (related person); Resources; Retinoscopy; Sample Size; Screening procedure; Severities; Strabismus; Testing; Vision; Vision Disorders; Vision Screening; experience; group support; handicapping condition; meetings; prevent; tool; user-friendly; web site

DESCRIPTION (provided by applicant): The proposed project will utilize the comprehensive dataset from the Vision in Preschoolers (VIP) Study, a multi-center, cross-sectional, two-phased study sponsored by the National Eye Institute, to address unanswered questions that are of clinical and public health importance in vision screening. The specific aims of this proposal do not include the major goals of the VIP Study, which were already accomplished and published. Instead, the proposed project involves the additional analysis of the VIP data to address the following important new aims, some of which were raised by experts during the National Eye Institute-sponsored Expert Panel Meeting in July 2005: (1) Evaluate the validity of noncycloplegic retinoscopy, Retinomax Autorefractor, SureSight Vision Screener, and Lea Symbols VA test for detecting VIP-defined hierarchical Group 1 conditions only (most severe), Group 1 & 2 conditions (most and moderately severe), all VIP-targeted vision conditions, and for detecting each specific type of refractive error (myopia, hyperopia, astigmatism, and anisometropia) with various levels of severity, by using receiver operating characteristic (ROC) analysis. Make ROC results available to the public through an interactive, user- friendly website. (2) Examine the relation between anisometropia and unilateral amblyopia and between bilateral high refractive error and bilateral amblyopia, and the differences in their relation as a function of age of the child. (3) Determine the ethnic-specific prevalence of VIP-targeted vision conditions among Head Start preschool children. The VIP dataset is a unique resource to evaluate the operating characteristics of the best-performing vision screening tools that are now being used widely by organizations that conduct preschool vision screening, and to better understand vision conditions among preschoolers. The very large sample size (N=4,040), as well as the experience and high productivity of the VIP Study Group, support the feasibility and likelihood of high yield of the proposed project.

描述（由申请人提供）：拟议项目将利用学龄前儿童视力 (VIP) 研究的综合数据集，这是一项由国家眼科研究所赞助的多中心、横断面、两阶段研究，旨在解决视力筛查中具有临床和公共卫生重要性的未解答问题。本提案的具体目标不包括已经完成并发布的 VIP 研究的主要目标。相反，拟议的项目涉及对 VIP 数据进行额外分析，以解决以下重要的新目标，其中一些目标是由专家在 2005 年 7 月国家眼科研究所主办的专家小组会议上提出的：(1) 评估非散瞳验光检影、Retinomax 自动验光仪、SureSight 视力筛查仪和 Lea Symbols VA 测试的有效性，仅用于检测 VIP 定义的分层第 1 组病症（大多数 严重）、第 1 组和第 2 组状况（最严重和中度严重）、所有 VIP 目标视力状况，以及通过使用受试者工作特征 (ROC) 分析来检测不同严重程度的每种特定类型的屈光不正（近视、远视、散光和屈光参差）。通过交互式、用户友好的网站向公众提供 ROC 结果。 (2) 检查屈光参差与单侧弱视之间、双侧高屈光不正与双侧弱视之间的关系，以及它们之间的关系随儿童年龄的变化的差异。 (3) 确定 Head Start 学龄前儿童中 VIP 目标视力状况的种族特定患病率。 VIP 数据集是一个独特的资源，用于评估性能最佳的视力筛查工具的操作特征，这些工具目前被进行学前视力筛查的组织广泛使用，并更好地了解学龄前儿童的视力状况。非常大的样本量（N = 4,040）以及 VIP 研究小组的经验和高生产力支持了拟议项目的可行性和高产量的可能性。