Healthy Aging In Neighborhoods of Diversity Across the Life Span (HANDLS)

一生中多元化社区的健康老龄化 (HANDLS)

• 批准号: 7732248
• 负责人: michele k evans
• 金额: $ 293.85万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732248
• 关键词: Address; Adult; African American; Age; Age Distribution; American; Area; Automobile Driving; Baltimore; Behavioral; Binding; Biocompatible Materials; Biological Factors; Biological Markers; Blood Chemical Analysis; Body Composition; Bone Density; Cardiovascular Diseases; Cardiovascular system; Censuses; Characteristics; Cherry - dietary; Cities; Clinical Research; Cognition; Cognitive; Communities; Complex; Condition; DNA Repair; Data; Dental; Development; Disease; Environment; Environmental Risk Factor; Epidemiologic Studies; Evaluation; Failure; Family history of; Gender; Genetic; Guidelines; Health; Health Services Accessibility; Health Status; Heart Rate; Height; Hematology; Home environment; Household; Housing; Human; Impaired cognition; Incidence; Income; Individual; Interview; Laboratories; Literature; Longevity; Longitudinal Studies; Measurement; Measures; Medical; Medical History; Medical Research; Methodology; Methods; Minority; Molecular; Morbidity - disease rate; Musculoskeletal; Neighborhoods; Occupations; Outcome; Oxidative Stress; Participant; Pathway interactions; Performance; Phase; Physical Examination; Physical Function; Poverty; Probability; Probability Samples; Proxy; Psychophysiology; Psychosocial Factor; Questionnaires; Race; Rate; Recording of previous events; Recruitment Activity; Reporting; Research; Research Design; Risk; Risk Factors; Role; Sample Size; Sampling; Sampling Studies; Screening procedure; Services; Site; Societies; Socioeconomic Status; Surveys; Thick; Time; Translational Research; Ultrasonography; Visit; Weight; Work; age difference; age related; aged; base; bone quality; cohesion; cohort; demographics; design; follow-up; forest; health care quality; health care service utilization; health disparity; healthy aging; improved; low socioeconomic status; mortality; multidisciplinary; muscle strength; novel; nutrition; pre-clinical; prospective; psychosocial; racism; sex; social; social capital; socioeconomics; tool

The HANDLS study is a prospective, epidemiologic, longitudinal study of a baseline representative sample of African Americans and whites between 30-64 years old recruited as a fixed cohort of participants by household screenings from an area probability sample of twelve census segments in Baltimore City. The HANDLS design is an area probability sample of Baltimore based on the 2000 Census. Using this methodology, working with survey statisticians we chose 12 neighborhoods to meet race by SES by age distribution because they were likely to yield representative distributions of Baltimore City with sufficient individuals to fill the sampling design based. Within the 12 neighborhoods, housing units are selected with a known non-zero chance of selection. The addresses are screened for individuals who meet the age-gender-race-poverty sample size, and those were chosen to be included in the sample using a probability sampling method. From these probabilities we can compute weights to adjust for unequal probabilities of selection. These weights will be needed to compute estimates that combine subjects across any of the age-gender-race-poverty group. The poverty status delimiter is 125% poverty based on 125% of the 2004 Health and Human Services Poverty Guidelines. The initial examination and recruitment phase will take approximately 4 years to complete. The study data is being collected in two parts. The first part consists of an in-home interview that includes questionnaires about the participants health status, health service utilization, psychosocial factors, nutrition, neighborhood characteristics, and demographics. The second part is collected on the medical research vehicles and includes medical history and physical examination, dietary recall, cognitive evaluation, psychophysiology assessments including heart rate variability, arterial thickness, carotid ultrasonography, assessments of muscle strength and bone density, and laboratory measurements (blood chemistries, hematology, biomarkers of oxidative stress and biomaterials for genetic studies). Ultimately, the baseline HANDLS sample will consist of approximately 4,000 community-dwelling African American and white adults aged 30-64. Using our mobile medical research vehicles, we visit each census tract for 4 months and we will re-visit every census tract in a 3.5-year cycle. Thus far HANDLS has recruited 3182 participants in the South Baltimore, Reservoir Hill, Cherry Hill, Govans, Forest Park, Highlandtown, Morrell Park, Curtis Bay, Park Heights, Frankford, South Hilton and Penrose neighborhoods of Baltimore. This is approximately 80% of the planned total cohort, specifically 3,182 participants: 1,977 African Americans (62%) and 1,205 whites (38%).Approximately 45% of the cohort reported a household income below the 125% poverty status delimiter. Of those below the 125% poverty delimiter, 31% were white and 69% African American. Of those above the 125% poverty delimiter, 44% were white and 56% African American. The mean age of the sample was 47.9 years. There were no significant age differences associated with sex or race. Participants below the 125% poverty delimiter were slightly younger than those above the delimiter. Covariates: Other variables include nutrition, environment and neighborhood effects, genetic make-up, family history, activity level, access to health care, and prevalent medical, dental, psychiatric conditions, oxidative stress, and DNA repair capacity which may modulate the effects of SES and race on cardiovascular, musculoskeletal, cognitive, and autonomic functioning.

HANDLS研究是一项前瞻性、流行病学、纵向研究，对30-64岁之间的非裔美国人和白人的基线代表性样本进行研究，通过家庭筛选，从巴尔的摩市12个人口普查部分的区域概率样本中招募固定队列参与者。HANDLS设计是基于2000年人口普查的巴尔的摩区域概率样本。使用这种方法，与调查统计学家合作，我们选择了12个社区，根据社会经济地位和年龄分布来满足种族，因为它们可能产生巴尔的摩市的代表性分布，有足够的个人来填补抽样设计的基础。在12个社区中，住房单元的选择是已知的非零选择机会。对符合年龄、性别、种族和贫困样本量的个人进行地址筛选，并使用概率抽样方法选择将其纳入样本。从这些概率中，我们可以计算权重来调整不相等的选择概率。这些权重将用于计算综合任何年龄、性别、种族和贫困群体的受试者的估计。根据2004年《卫生和人类服务贫困准则》的125%，贫困状况的界限为125%。

项目成果

The Association of Loneliness with Diabetes Is Mediated by Physical Activity and BMI but Not Diet Quality.

• DOI: 10.3390/nu15234923
• 发表时间: 2023-11-25
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Kuczmarski MF;Orsega-Smith E;Evans MK;Zonderman AB
• 通讯作者: Zonderman AB

Pro-Inflammatory Diets Are Associated with Frailty in an Urban Middle-Aged African American and White Cohort.

• DOI: 10.3390/nu15214598
• 发表时间: 2023-10-29
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Kuczmarski MF;Beydoun MA;Georgescu MF;Noren Hooten N;Mode NA;Evans MK;Zonderman AB
• 通讯作者: Zonderman AB

C-reactive protein in the prediction of cardiovascular events.

C反应蛋白在心血管事件的预测中的作用。

• 发表时间: 2003
• 期刊: The New England journal of medicine
• 作者: Evans,MicheleK;Zonderman,AlanB;Johnson,WallaceR
• 通讯作者: Johnson,WallaceR

Association of DASH and Depressive Symptoms with BMI over Adulthood in Racially and Socioeconomically Diverse Adults Examined in the HANDLS Study.

HANDLS 研究中调查的种族和社会经济多样化成年人中 DASH 和抑郁症状与成年期 BMI 的关联。

• DOI: 10.3390/nu11122934
• 发表时间: 2019
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: FanelliKuczmarski,Marie;Hossain,Sharmin;Beydoun,MayA;Maldonando,Ana;Evans,MicheleK;Zonderman,AlanB
• 通讯作者: Zonderman,AlanB

Kullback-Leibler clustering of continuous wavelet transform measures of heart rate variability.

心率变异性连续小波变换测量的 Kullback-Leibler 聚类。

• 发表时间: 2004
• 期刊: Biomedical sciences instrumentation
• 作者: Mager,DonaldE;Merritt,MarcellusM;Kasturi,Jyotsna;Witkin,LisaR;Urdiqui-Macdonald,Mirna;Sollers3rd,JohnJ;Evans,MicheleK;Zonderman,AlanB;Abernethy,DarrellR;Thayer,JulianF
• 通讯作者: Thayer,JulianF