Clinical And Therapeutic Studies Of Human Filariasis and Related Diseases

人类丝虫病及相关疾病的临床和治疗研究

• 批准号: 7732456
• 负责人: Thomas B Nutman
• 金额: $ 36.3万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732456
• 关键词: Angioneurotic Edema; Benign; Blood; Clinical; Clinical Trials; Clinical assessments; Communicable Diseases; Condition; Development; Diagnosis; Disease; Eosinophilia; Fibrosis; Filarial Elephantiases; Filariasis; Goals; HIV; Helminths; Human; Idiopathic Hypereosinophilic Syndromes; India; Infection; Loiasis; Lymphatic; Lymphocyte; Malaria; Mali; Mediating; Methods; Molecular; Onchocerciasis; Parasites; Pathogenesis; Pathway interactions; Patients; Prevention; Reverse Transcriptase Polymerase Chain Reaction; Strongyloides; Strongyloidiasis; Therapeutic Studies; Tissues; Tuberculosis; eosinophil; novel diagnostics

To understand better the pathogenesis of filarial infections (onchocerciasis, loiaisis, lymphatic filarasis) clinical assessments of patients with these and other related non-filarial (strongyloides, malaria) infections have been studied in detail. The influence that filarial infections have on the clinical expression of non-filarial infectious diseases have also been studied by performing clinical trials in filarial-endemic regions of the world that are co-endemic for malaria (Mali), tuberculosis (India) and HIV (India). Understanding of the pathogenesis of eosinophil-related disorders has been a major focus of our clinically related studies. Multiple groups of hypereosinophilic patients (parasite-infected, familial hypereosinophilia, idiopathic hypereosinophilic syndrome, benign hypereosinophilia, episodic angioedema with eosinophilia) have been assessed clinically; moreover, lymphocytes (and their subsets) and eosinophils have been examined functionally and at the molecular level (human microarrays and RT-PCR) to identify the molecules and pathways involved in conditions associated with increased blood and tissue eosinophilia as well the fibrosis that the tissue eosinophilia induces. New diagnostic approaches have been developed and utilized for the rapid and specific diagnosis of Strongyloidiasis, loiasis, and onchocerciasis.

为了更好地了解丝虫感染（盘尾丝虫病、洛伊斯病、淋巴丝虫病）的发病机制，对这些和其他相关非丝虫（类圆线虫病、疟疾）感染患者的临床评估进行了详细研究。还通过在疟疾（马里）、结核病（印度）和艾滋病毒（印度）共同流行的世界丝虫病流行地区进行临床试验，研究了丝虫感染对非丝虫性传染病临床表现的影响。 了解嗜酸性粒细胞相关疾病的发病机制一直是我们临床相关研究的重点。 多组嗜酸性粒细胞增多患者（寄生虫感染、家族性嗜酸性粒细胞增多症、特发性嗜酸性粒细胞增多综合征、良性嗜酸性粒细胞增多症、阵发性血管性水肿伴嗜酸性粒细胞增多症）已进行临床评估;此外，本发明还淋巴细胞（及其亚群）和嗜酸性粒细胞的功能和分子水平进行了研究（人类微阵列和RT-PCR）以确定与血液和组织嗜酸性粒细胞增多以及组织纤维化相关的疾病中涉及的分子和途径，嗜酸性粒细胞增多症诱导。 新的诊断方法已被开发和利用，用于快速和特异性诊断类圆线虫病、盘尾丝虫病和盘尾丝虫病。

项目成果

Filariasis in travelers presenting to the GeoSentinel Surveillance Network.

• DOI: 10.1371/journal.pntd.0000088
• 发表时间: 2007-12-26
• 期刊: PLoS neglected tropical diseases
• 影响因子: 3.8
• 作者: Lipner EM;Law MA;Barnett E;Keystone JS;von Sonnenburg F;Loutan L;Prevots DR;Klion AD;Nutman TB;GeoSentinel Surveillance Network
• 通讯作者: GeoSentinel Surveillance Network

Infectious diseases of international travel.

国际旅行的传染病。

• 发表时间: 2001
• 期刊: Advances in internal medicine
• 作者: Klion,AD;Nutman,TB
• 通讯作者: Nutman,TB

"Pseudo-conduction block" in a patient with vasculitic neuropathy.

血管炎性神经病患者的“伪传导阻滞”。

• 发表时间: 2001
• 期刊: Electromyography and clinical neurophysiology
• 作者: Sandbrink,F;Klion,AD;Floeter,MK
• 通讯作者: Floeter,MK

Cutaneous onchocerciasis in an American traveler.

一名美国旅行者患有皮肤盘尾丝虫病。

• DOI: 10.1111/j.1365-4632.2004.02203.x
• 发表时间: 2005
• 期刊: International journal of dermatology
• 影响因子: 3.6
• 作者: Nguyen,JosephineC;Murphy,MichaelE;Nutman,ThomasB;Neafie,RonaldC;Maturo,Stephen;Burke,DonaldS;Turiansky,GeorgeW
• 通讯作者: Turiansky,GeorgeW

Approach to the therapy of hypereosinophilic syndromes.

嗜酸性粒细胞增多综合征的治疗方法。

• DOI: 10.1016/j.iac.2007.07.006
• 发表时间: 2007
• 期刊: Immunology and allergy clinics of North America
• 影响因子: 2.6
• 作者: Klion,AmyD