Center for Genetic Research, Ethics, and Law

基因研究、伦理和法律中心

• 批准号: 7491830
• 负责人: Eric T Juengst
• 金额: $ 107.33万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2010-08-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7491830
• 关键词: Agreement; Architecture; Belief; Collaborations; Communities; Ethics; Family; Fostering; Gene Transfer Techniques; Genetic Research; Genomics; Human; Incentives; Individual; Interdisciplinary Study; Laws; Mission; Participant; Policies; Population; Range; Reaction; Regulation; Research; Research Ethics; Research Ethics Committees; Research Training; Resources; Scholarship; Science Policy; Structure; Technology; Training Programs; Variant; base; cultural values; design; ethical legal social implication; experience; improved; lens; practical application

DESCRIPTION (provided by applicant): The mission of the proposed Center for Genetics Research Ethics and Law (CGREL) is to foster sustained interdisciplinary research on the ethical, legal, and social issues involved in the design and conduct of human genetics research with individuals, families, communities, and populations. CWRU already hosts a variety of research efforts relevant to the CGREL's theme. The CGREL will integrate these efforts to launch new research collaborations and provide the resource structure necessary for their application to high priority genetics research policy questions. The basic architecture of the CGREL consists of six overlapping research groups, six research resource cores, and a research training program. The research collaborations generated by the CGREL will be harnessed to pursue four Center-Wide research aims, which we believe reflect the highest priority needs in genetic research ethics and policymaking: 1. To improve our understanding of the relationship between human genetics research and the humans it seeks to benefit by elucidating the cultural values and beliefs that influence different people's reactions to and experience of genetics research participation. 2. To improve our understanding of the relationship between human genetics research and the human benefits it promises by elucidating the influence of translational incentives, ranging from commercial prospects to benefit-sharing agreements, on the design and conduct of basic genetics research. 3. To anticipate the research ethics and science policy issues raised by new advances in genetics research by analyzing the confluence of human variation research, computational genomics, sequencing technologies, and gene transfer techniques through the lenses of contemporary research regulations and norms. 4. To harness ongoing scholarship on genetics research ethics for practical application by providing evidence-based policy options for use by the scientific community, institutional review boards, and national research regulatory bodies in seeking to improve participant protections in the design and conduct of human genetic research.

描述（由申请人提供）：拟议的遗传学研究伦理与法律中心（CGREL）的使命是促进持续的跨学科研究的伦理，法律的和社会问题，涉及设计和进行人类遗传学研究与个人，家庭，社区和人群。CWRU已经主办了各种研究工作相关的CGREL的主题。CGREL将整合这些努力，以启动新的研究合作，并提供必要的资源结构，使其应用于高度优先的遗传学研究政策问题。 CGREL的基本架构包括六个重叠的研究小组，六个研究资源核心和一个研究培训计划。CGREL产生的研究合作将被利用来追求四个中心范围的研究目标，我们认为这反映了遗传研究伦理和政策制定的最高优先需求： 1.为了提高我们对人类遗传学研究与人类之间关系的理解，它试图通过阐明影响不同人对遗传学研究参与的反应和体验的文化价值观和信仰来获益。 2.通过阐明从商业前景到利益分享协议等转化激励措施对基础遗传学研究的设计和实施的影响，提高我们对人类遗传学研究与其所承诺的人类利益之间关系的理解。 3.通过分析人类变异研究，计算基因组学，测序技术和基因转移技术的融合，通过当代研究法规和规范的镜头，预测遗传学研究的新进展所提出的研究伦理和科学政策问题。 4.为了将遗传学研究伦理学方面的现有学术成果用于实际应用，提供基于证据的政策选择供科学界使用， 董事会和国家研究监管机构寻求改善参与者的保护， 人类基因研究的设计和实施。