Enhancement Ethics and the Molecular Genetics of Aging

描述（由申请人提供）： 细胞老化提高了干预人类衰老过程的前景， 极大地延长了人类的寿命。制定此类干预措施 将使社会面临解释、使用和监管的挑战， 终极基因增强技术：一项可以让我们 在细胞水平上改变人类生命的基本常数。 本项目旨在联合收割机的两个正在进行的研究计划的工作 来开始应对这些挑战。第一个是埃里克 Juengst、麦克斯韦梅尔曼和托马斯默里一直在进行道德研究， 以及遗传增强通常带来的公共政策挑战 技术.伦理分析和公共政策制定的框架 将被应用到抗衰老的案例中 干预措施，既作为对框架的测试，也看看它在 这个案子第二个资源是其他共同调查员的工作， 斯蒂芬·波斯特、彼得·怀特豪斯和罗伯特·宾斯托克，关于临床和社会 人类衰老过程的意义。这项研究将用于确定 在这个项目中分析的问题，通过提供当代景观 社会实践、价值观和信仰， 挑战.通过合作，我们将努力预测 抗衰老干预措施可以提高三个选区：个人 以及可能使用它们的家庭， 他们和公共政策制定者将塑造他们的环境， 可能会变得可用。该项目的方法将是分析和论述： 我们将在以下基础上批判、构建和提出论点： 现有的信息和我们以前的工作，通过定期的方案， 研究会议和合作写作。这项工作将由一名 顾问专家组;卡罗尔·唐利，联合主任，文学中心， 希拉姆学院的医学和卫生专业;迈克尔·福塞尔，编辑， 抗衰老医学杂志;琳达乔治，副主任，中心 杜克大学的老龄化和人类发展研究;和托马斯默里， 总统黑斯廷斯中心

DESCRIPTION (provided by applicant): Advances in the molecular genetics of cellular aging raise the prospect of intervening in the human aging process to dramatically extend the human life span. The development of such interventions would confront society with the challenge of interpreting, using and regulating the ultimate genetic enhancement technology: a technology that could allow us to change a basic constant of human life at the cellular level. This project is designed to combine the work of two ongoing research programs to begin to address these challenges. The first is the research that Eric Juengst, Maxwell Mehlman and Thomas Murray have been conducting on the ethical and public policy challenges that are posed generically by genetic enhancement technologies. The framework for ethical analysis and public policy development generated by that research would be applied here to the case of anti-aging interventions, both as a test of the framework and to see what it yields in this case. The second resource is the work of the other co-investigators, Stephen Post, Peter Whitehouse and Robert Binstock, on the clinical and social meanings of the human aging process. That research will be used to identify the issues to analyze in this project, by providing the landscape of contemporary social practices, values and beliefs that radical life extensions could challenge. Collaboratively, we will seek to anticipate the issues that anti-aging interventions could raise for three constituencies: the individuals and families that might use them, the health professionals that might provide them, and the public-policy makers that will shape the context in which they might become available. The project's methods will be analytic and discursive: we will be critiquing, constructing and proposing arguments on the basis of existing information and our previous work, through a regimen of regular research meetings and collaborative writing. This work will be overseen by an expert group of advisors; Carol Donley, Co-director, Center for Literature, Medicine and the Health Profession at Hiram College; Michael Fossel, Editor, Journal of Anti-Aging Medicine; Linda George, Associate Director, Center for the Study of Aging and Human Development, Duke University; and Thomas Murray, President, The Hastings Center.