Neuroimaging Core

神经影像核心

• 批准号: 7656684
• 负责人: GUIDO GERIG
• 金额: $ 28.03万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7656684
• 关键词: 6 year old; Address; Adolescence; Adolescent; Adult; Age; Age-Years; Allegra; Amygdaloid structure; Anisotropy; Archives; Arts; Bioinformatics; Biostatistics Core; Brain; Brain imaging; Child; Classification; Clinical; Collaborations; Coupled; Data; Data Analyses; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Ensure; Feedback; Functional Magnetic Resonance Imaging; Funding; Growth; Head; Hippocampus (Brain); Image; Image Analysis; Infant; Joints; Laboratories; Left; Lobar; Lobe; Location; Longitudinal Studies; Magnetic Resonance Imaging; Manuals; Measurement; Medical Imaging; Methodology; Methods; Mission; Pathway Analysis; Pathway interactions; Physiologic pulse; Preparation; Process; Property; Protocols documentation; Psychiatry; Pulse taking; Quality Control; Radiology Specialty; Range; Research; Research Personnel; Risk; Sampling; Scheme; Schizophrenia; Seeds; Services; Site; Statistical Data Interpretation; Structure; Technology; Testing; Thick; Tissues; United States National Institutes of Health; Validation; base; brain tissue; computerized data processing; experience; gray matter; image processing; image registration; improved; innovation; insight; interest; lateral ventricle; morphometry; neonate; neuroimaging; novel; pre-clinical research; programs; quality assurance; tool; white matter

The primary objective of the Neuroimaging Core is to serve the clinical Projects 1 and 2 which utilize MRI image acquisition and processing technology.. The core provides quantitative measurements of structural MRI (sMRI), MR Diffusion Tensor Imaging (DTI), and functional MRI (fMRI), and prepares the quantitative results for analysis by the Biostatistics Core. The core utilizes images from state-of-the-art high-field scanner MRI technology, and ensures optimized pulse sequences for imaging of neonates and young children (3T Siemens Allegra head-only) and adolescents. (3T GE). The core will provide well established and validated image analysis methods and will also introduce novel methods driven by the needs of these projects. Given the specialized expertise of our multi-disciplinary group and the close collaboration of our researchers with other large national programs which are of crucial importance for this project (Bioinformatics Research Network BIRN, National Alliance of Medical Image Computing NA-MIC, NLM- sponsored Insight Toolkit ITK developments), we will not only provide service to projects with well- established methodology, but will continue to develop advanced, novel image processing tools necessary to advance the field. This Core enables Center investigators to utilize optimal methods for image data analysis using the full range of MRI capabilities, and thus enables imaging research which addresses highly relevant pre-clinical research of brain development and alterations thereof in subjects at risk for schizophrenia. Focusing on the earliest age range possible for neuroimaging (neonates to 6 year old subjects) with studying brain growth in a longitudinal study (which provides a perspective that is unattainable with cross-sectional samples), and secondly focusing on altered brain structure and function in children and adolescence at genetric risk for schizophrenia, coupled with applying novel innovative image analysis tools, are all in accordance with the mission of NIH funded projects to get better insight into cause and origin of disease.

Neuroimaging Core的主要目标是为使用MRI的临床项目1和2提供服务 图像采集与处理技术岩心提供了结构的定量测量， MRI（sMRI）、MR扩散张量成像（DTI）和功能性MRI（fMRI），并准备定量 结果由生物统计学核心进行分析。核心利用了最先进的高场图像 扫描仪MRI技术，并确保为新生儿和年轻人成像优化脉冲序列 儿童（3 T Siemens Allegra仅头部）和青少年。(3T GE）。核心将提供完善的 和验证的图像分析方法，并将介绍由这些需求驱动的新方法 项目鉴于我们的跨专业小组的专业知识和我们的密切合作， 研究人员与其他大型国家计划，这是至关重要的这个项目 （生物信息学研究网络BIRN，国家医学图像计算联盟NA-MIC，NLM- 赞助的Insight Toolkit ITK开发），我们将不仅为具有良好- 建立的方法，但将继续开发先进的，新颖的图像处理工具， 推进领域。该核心使中心研究人员能够利用最佳方法进行图像数据分析 使用全方位的MRI功能，从而使成像研究，解决高度相关的 在有精神分裂症风险的受试者中进行脑发育及其改变的临床前研究。 重点关注可能进行神经成像的最早年龄范围（新生儿至6岁受试者）， 在纵向研究中的大脑生长（这提供了一个横向研究无法实现的视角）， 样本），其次关注儿童和青少年大脑结构和功能的改变， 精神分裂症的遗传风险，再加上应用新颖的创新图像分析工具，都在 根据NIH资助项目的使命，更好地了解疾病的原因和起源。