1/2 Development of a Screening Interview for Research Studies of ASD

1/2 开发 ASD 研究筛选访谈

• 批准号: 7844115
• 负责人: Catherine Lord
• 金额: $ 61.71万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7844115
• 关键词: Address; Adolescent; Adult; Advisory Committees; Age; Age of Onset; Algorithms; American Psychological Association; Anxiety; Anxiety Disorders; Appointment; Area; Attention deficit hyperactivity disorder; Authorship; Autistic Disorder; Behavior; Behavioral; Brain; Child; Clinic; Clinical; Clinical Research; Collection; Communication; Communication impairment; Communities; Conflict (Psychology); Data; Data Collection; Data Set; Databases; Decision Making; Development; Device or Instrument Development; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Discipline; Disease; Doctor of Philosophy; Down Syndrome; Effectiveness; Electronic Mail; Eligibility Determination; Ensure; Etiology; Evaluation; Exhibits; Face; Faculty; Family; Fellowship; Fetal Alcohol Syndrome; Follow-Up Studies; Foundations; Fragile X Syndrome; Funding; Genetic; Genetic screening method; Growth and Development function; Housing; Human; Individual; Infant; Intellectual functioning disability; Intervention; Interview; Investigation; Joints; Knowledge; Language; Language Delays; Lead; Leadership; Location; Longitudinal Studies; Measures; Medical center; Methods; Michigan; National Institute of Mental Health; National Institute on Deafness and Other Communication Disorders; New York; Paper; Parents; Participant; Patients; Pediatric Hospitals; Pediatrics; Persons; Phenotype; Physicians; Population; Positioning Attribute; Postdoctoral Fellow; Preschool Child; Principal Investigator; Probability; Problem behavior; Procedures; Property; Psychiatry; Psychology; Qualifying; Questionnaires; Randomized Controlled Trials; Recommendation; Records; Recruitment Activity; Reporting; Research; Research Design; Research Ethics Committees; Research Personnel; Research Project Grants; Resolution; Resources; Risk; Role; Sampling; School-Age Population; Screening procedure; Sensitivity and Specificity; Services; Site; Source; Special Education; Specificity; Speed; Students; Subgroup; Symptoms; Teleconferences; Telephone; Testing; Time; Toddler; Training; Travel; Triage; United States Health Resources and Services Administration; United States National Institutes of Health; Universities; Validation; Visit; Walking; Wisconsin; Work; autism spectrum disorder; base; clinical Diagnosis; experience; graduate student; instrument; interest; medical specialties; meetings; new technology; phrases; professor; programs; public health relevance; repository; research study; response; service intervention; social; social communication; teacher; tertiary care; virtual

DESCRIPTION (provided by applicant): To enhance participant recruitment efforts for genetics studies and other large- scale etiological research efforts, there is a need for an instrument that can be practically and efficiently employed in research studies of autism spectrum disorders (ASD). The current proposal aims to develop a research screening instrument that is based on questions from the Autism Diagnostic Interview-Revised (ADI-R; Rutter et al., 2003), but that is substantially shorter and easier to administer. The newly developed ADI Research Screening Interview will be appropriate for use in person or on the telephone. Development of the ADI Research Screening Interview will involve two large samples of children with ASD and non-ASD diagnoses. Existing data from a total of 979 assessments of children with ASD and 257 assessments of children with non-ASD diagnoses will be used to develop the instrument. A separate group of approximately 180 participants with ASD and 240 with non-ASD diagnoses will be recruited from ongoing research studies and specialty diagnostic clinics to test the new measure. Given recent findings that children with certain non-ASD diagnoses are often misclassified by ASD screening and diagnostic measures (e.g., Towbin et al., 2005; Bishop, et al., 2007), a particular strength of this proposal is the recruitment of children with targeted non-ASD diagnoses, including intellectual disability (ID), attention deficit hyperactivity disorder (ADHD), anxiety disorder, and an early developmental risk group. With the advent of new technologies making genetic testing more accessible and less expensive, researchers are increasingly calling for a way to rapidly screen large populations for ASD first, and then carry out more intensive phenotyping after genetic tests are analyzed. The availability of a diagnostic screening instrument with high levels of sensitivity and specificity will dramatically reduce the time and expense that is currently required to determine diagnostic status of ASD research participants. The option of administering the screening protocol by telephone will facilitate access to more diverse participant populations for whom travel may be less feasible and who are traditionally under-represented in ASD research. PUBLIC HEALTH RELEVANCE: This proposal will result in the development of a new screening instrument to identify children with autism spectrum disorders (ASD). Several investigations are currently underway in order to better understand the causes of ASD. Many of these studies require very large numbers of participants; however, current methods for identifying participants for such studies are often expensive and time-consuming and require intensive training. To address these issues, we aim to create a short parent interview that can be administered on the telephone to quickly identify potential participants for ASD research. This new instrument will facilitate research into ASD etiology by increasing the speed and effectiveness of participant recruitment efforts. In addition, such an instrument may have other practical uses clinically. In communities where the wait for an ASD evaluation is extremely long or there are no local resources for diagnostic evaluations, an efficient screening instrument that could be administered by phone might help triage children in need of further evaluation and/or be used to qualify children for certain intervention services pending a more complete diagnostic evaluation at a later time.

描述（由申请人提供）：为了加强遗传学研究和其他大规模病因学研究工作的参与者招募工作，需要一种可以实际有效地用于自闭症谱系障碍（ASD）研究的工具。目前的提案旨在开发一种基于自闭症诊断访谈修订版（ADI-R；Rutter 等人，2003）中的问题的研究筛查工具，但该工具的长度要短得多且更易于管理。新开发的 ADI 研究筛选访谈适合亲自使用或通过电话使用。 ADI 研究筛查访谈的开发将涉及患有自闭症谱系障碍 (ASD) 和非自闭症谱系障碍 (ASD) 诊断的儿童的两个大样本。该工具的开发将使用来自总共 979 项自闭症谱系障碍儿童评估和 257 项非自闭症谱系障碍儿童评估的现有数据。将从正在进行的研究和专业诊断诊所招募大约 180 名 ASD 参与者和 240 名非 ASD 诊断参与者组成的单独小组来测试新措施。鉴于最近发现某些非 ASD 诊断的儿童经常被 ASD 筛查和诊断措施错误分类（例如，Towbin 等人，2005 年；Bishop 等人，2007 年），该提案的一个特别优势是招募有针对性的非 ASD 诊断儿童，包括智力障碍（ID）、注意力缺陷多动障碍（ADHD）、焦虑症和早期发育风险群体。 随着新技术的出现使得基因检测变得更加容易和更便宜，研究人员越来越多地呼吁找到一种方法，首先快速筛查大量人群的自闭症谱系障碍，然后在分析基因检测后进行更深入的表型分析。具有高灵敏度和特异性的诊断筛查仪器的出现将大大减少目前确定 ASD 研究参与者的诊断状态所需的时间和费用。通过电话执行筛查方案的选择将有助于接触更多样化的参与者群体，对于这些参与者来说，旅行可能不太可行，并且传统上在自闭症谱系障碍研究中代表性不足。 公共卫生相关性：该提案将导致开发一种新的筛查工具来识别患有自闭症谱系障碍 (ASD) 的儿童。为了更好地了解自闭症谱系障碍的原因，目前正在进行多项调查。其中许多研究需要大量的参与者；然而，目前确定此类研究参与者的方法往往昂贵且耗时，并且需要强化培训。为了解决这些问题，我们的目标是创建一个简短的家长访谈，可以通过电话进行，以快速识别自闭症谱系障碍研究的潜在参与者。这一新工具将通过提高参与者招募工作的速度和有效性来促进自闭症谱系障碍病因学的研究。此外，这种仪器在临床上可能还有其他实际用途。在等待 ASD 评估的时间极长或当地没有诊断评估资源的社区，可以通过电话管理的高效筛查工具可能有助于对需要进一步评估的儿童进行分类和/或用于确定儿童是否有资格获得某些干预服务，以等待稍后进行更完整的诊断评估。