1/2 Development of a Screening Interview for Research Studies of ASD

1/2 开发 ASD 研究筛选访谈

• 批准号: 7844115
• 负责人: Catherine Lord
• 金额: $ 61.71万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7844115
• 关键词: Address; Adolescent; Adult; Advisory Committees; Age; Age of Onset; Algorithms; American Psychological Association; Anxiety; Anxiety Disorders; Appointment; Area; Attention deficit hyperactivity disorder; Authorship; Autistic Disorder; Behavior; Behavioral; Brain; Child; Clinic; Clinical; Clinical Research; Collection; Communication; Communication impairment; Communities; Conflict (Psychology); Data; Data Collection; Data Set; Databases; Decision Making; Development; Device or Instrument Development; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Discipline; Disease; Doctor of Philosophy; Down Syndrome; Effectiveness; Electronic Mail; Eligibility Determination; Ensure; Etiology; Evaluation; Exhibits; Face; Faculty; Family; Fellowship; Fetal Alcohol Syndrome; Follow-Up Studies; Foundations; Fragile X Syndrome; Funding; Genetic; Genetic screening method; Growth and Development function; Housing; Human; Individual; Infant; Intellectual functioning disability; Intervention; Interview; Investigation; Joints; Knowledge; Language; Language Delays; Lead; Leadership; Location; Longitudinal Studies; Measures; Medical center; Methods; Michigan; National Institute of Mental Health; National Institute on Deafness and Other Communication Disorders; New York; Paper; Parents; Participant; Patients; Pediatric Hospitals; Pediatrics; Persons; Phenotype; Physicians; Population; Positioning Attribute; Postdoctoral Fellow; Preschool Child; Principal Investigator; Probability; Problem behavior; Procedures; Property; Psychiatry; Psychology; Qualifying; Questionnaires; Randomized Controlled Trials; Recommendation; Records; Recruitment Activity; Reporting; Research; Research Design; Research Ethics Committees; Research Personnel; Research Project Grants; Resolution; Resources; Risk; Role; Sampling; School-Age Population; Screening procedure; Sensitivity and Specificity; Services; Site; Source; Special Education; Specificity; Speed; Students; Subgroup; Symptoms; Teleconferences; Telephone; Testing; Time; Toddler; Training; Travel; Triage; United States Health Resources and Services Administration; United States National Institutes of Health; Universities; Validation; Visit; Walking; Wisconsin; Work; autism spectrum disorder; base; clinical Diagnosis; experience; graduate student; instrument; interest; medical specialties; meetings; new technology; phrases; professor; programs; public health relevance; repository; research study; response; service intervention; social; social communication; teacher; tertiary care; virtual

DESCRIPTION (provided by applicant): To enhance participant recruitment efforts for genetics studies and other large- scale etiological research efforts, there is a need for an instrument that can be practically and efficiently employed in research studies of autism spectrum disorders (ASD). The current proposal aims to develop a research screening instrument that is based on questions from the Autism Diagnostic Interview-Revised (ADI-R; Rutter et al., 2003), but that is substantially shorter and easier to administer. The newly developed ADI Research Screening Interview will be appropriate for use in person or on the telephone. Development of the ADI Research Screening Interview will involve two large samples of children with ASD and non-ASD diagnoses. Existing data from a total of 979 assessments of children with ASD and 257 assessments of children with non-ASD diagnoses will be used to develop the instrument. A separate group of approximately 180 participants with ASD and 240 with non-ASD diagnoses will be recruited from ongoing research studies and specialty diagnostic clinics to test the new measure. Given recent findings that children with certain non-ASD diagnoses are often misclassified by ASD screening and diagnostic measures (e.g., Towbin et al., 2005; Bishop, et al., 2007), a particular strength of this proposal is the recruitment of children with targeted non-ASD diagnoses, including intellectual disability (ID), attention deficit hyperactivity disorder (ADHD), anxiety disorder, and an early developmental risk group. With the advent of new technologies making genetic testing more accessible and less expensive, researchers are increasingly calling for a way to rapidly screen large populations for ASD first, and then carry out more intensive phenotyping after genetic tests are analyzed. The availability of a diagnostic screening instrument with high levels of sensitivity and specificity will dramatically reduce the time and expense that is currently required to determine diagnostic status of ASD research participants. The option of administering the screening protocol by telephone will facilitate access to more diverse participant populations for whom travel may be less feasible and who are traditionally under-represented in ASD research. PUBLIC HEALTH RELEVANCE: This proposal will result in the development of a new screening instrument to identify children with autism spectrum disorders (ASD). Several investigations are currently underway in order to better understand the causes of ASD. Many of these studies require very large numbers of participants; however, current methods for identifying participants for such studies are often expensive and time-consuming and require intensive training. To address these issues, we aim to create a short parent interview that can be administered on the telephone to quickly identify potential participants for ASD research. This new instrument will facilitate research into ASD etiology by increasing the speed and effectiveness of participant recruitment efforts. In addition, such an instrument may have other practical uses clinically. In communities where the wait for an ASD evaluation is extremely long or there are no local resources for diagnostic evaluations, an efficient screening instrument that could be administered by phone might help triage children in need of further evaluation and/or be used to qualify children for certain intervention services pending a more complete diagnostic evaluation at a later time.

描述（由申请人提供）：为了加强遗传学研究和其他大规模的病因研究工作的参与者招聘工作，需要一种可以实际有效地用于自闭症谱系障碍研究（ASD）的工具。当前的提案旨在开发一种基于自闭症诊断面试重新审查的问题的研究筛查工具（ADI-R； Rutter等，2003），但这非常较短，更易于管理。新开发的ADI研究筛查访谈适用于亲自或电话。 ADI研究筛查访谈的开发将涉及两个有ASD和非ASD诊断的儿童样本。总共对ASD儿童和257个非ASD诊断儿童评估的儿童评估的现有数据将用于开发该工具。将从正在进行的研究研究和专业诊断诊所中招募一组大约180名ASD和240名具有非ASD诊断的参与者，以测试新措施。鉴于最近的发现，ASD筛查和诊断措施通常会误解了某些非ASD诊断的儿童（例如Towbin等，2005； Bishop等，2007），该提议的特殊优势是招募有针对性的非ASD诊断的儿童，包括智力障碍（ID）焦虑症（包括）焦虑症（包括），包括焦虑症和焦虑症（包括），以及一定的焦虑症（一定的焦虑症），一定的焦虑症，指的是，及其焦虑症，指的是，及其焦虑症。 随着新技术的出现使基因检测更加易于访问和更便宜，研究人员越来越多地呼吁一种迅速筛选大量人群的ASD，然后在分析基因测试后进行更深入的表型。具有高度敏感性和特异性的诊断筛查工具的可用性将大大减少确定ASD研究参与者诊断状态所需的时间和费用。通过电话管理筛选协议的选择将有助于访问更多的参与者人群，而旅行可能不那么可行，并且传统上对ASD研究的代表性不足。 公共卫生相关性：该提案将导致开发一种新的筛查工具，以识别患有自闭症谱系障碍的儿童（ASD）。目前正在进行一些调查，以便更好地了解ASD的原因。这些研究中有许多需要大量的参与者。但是，目前用于识别此类研究参与者的方法通常是昂贵且耗时的，需要进行深入的培训。为了解决这些问题，我们旨在创建一个简短的父母面试，该面试可以在电话中进行管理，以快速确定潜在的ASD研究参与者。这种新工具将通过提高参与者招聘工作的速度和有效性来促进对ASD病因的研究。此外，这种仪器在临床上可能具有其他实际用途。在等待ASD评估非常长的社区中，或者没有本地资源进行诊断评估，可以通过电话进行管理的有效筛选工具可能有助于需要进一步评估的分类儿童和/或用于限定儿童以进行某些干预服务，以便以后进行更完整的诊断评估。