Development of a Brief Screener for Research in Autism Spectrum Disorders

开发用于自闭症谱系障碍研究的简短筛选器

• 批准号: 7842354
• 负责人: Catherine Lord
• 金额: $ 49.88万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7842354
• 关键词: Address; Age; Age of Onset; Algorithms; Area; Autacoids; Autistic Disorder; Cell Aging; Cells; Child; Clinic; Clinical; Clinical Research; Data; Data Analyses; Data Set; Development; Device or Instrument Development; Diagnosis; Diagnostic; Epidemiology; Evaluation Research; Genetic; Individual; Interview; Investigation; Language; Measures; Parents; Participant; Population; Probability; Questionnaires; Recording of previous events; Recruitment Activity; Reporting; Research; Research Personnel; Robin bird; Sampling; Schedule; Screening procedure; Sensitivity and Specificity; Siblings; Site; Special Education; Symptoms; Testing; Time; Toddler; Training; Validation; Walking; Work; age group; autism spectrum disorder; base; cell age; clinical Diagnosis; design; developmental disease; experience; instrument; medical specialties; phrases; research study; response; social; social communication

DESCRIPTION (provided by applicant): This application entitled "Development of a Brief Screener for Research in Autism Spectrum Disorders" addresses broad challenge area (04) Clinical Research, 04-MH-101* Autism: Addressing the challenge. The proposal aims to develop a research screening instrument based on questions from the Social Communication Questionnaire (SCQ: Rutter, Bailey, & Lord, 2003) and the Autism Diagnostic Interview- Revised (ADI-R; Rutter, LeCouteur & Lord, 2003) that can be more effectively and practically employed in research studies of autism spectrum disorders (ASD). The newly developed measure will be the ADI Research Screening Questionnaire, a brief parent-report instrument that is designed to identify ASD in children ages 2 to 18 years. Development and validation of the new measure will involve two very large groups of children from multiple sites across the U.S. Existing data from a total of 2293 assessments of children with ASD, 792 assessments of children with non-ASD diagnoses, and 600 typically developing siblings of children with ASD will form the basis of the Measure Development sample. A separate sample of 1340 participants with ASD, 510 participants with non-ASD diagnoses, and 200 typically developing siblings of children with ASD will be recruited from ongoing research studies and specialty diagnostic clinics to validate the newly developed measure. Analyses of data from these two independent samples will result in a new instrument that can be used to rapidly ascertain potential participants for ASD research. The availability of a measure that quickly and accurately differentiates children with ASD from children with other developmental disorders will be invaluable to etiological and epidemiological research efforts, as it will significantly reduce the time and expense that is currently required to designate study participants as either having or not having ASD. Development of a Brief Screener for Research in Autism Spectrum Disorders This project will result in the development of a new screening instrument that can be used for research studies of autism spectrum disorders (ASD). Because of the need to identify large numbers of participants for genetics studies and other investigations of the causes of ASD, researchers require a way to rapidly screen large numbers of children and identify those who are highly likely to have a diagnosis of ASD. This project will provide researchers with the ability to quickly select potential participants so that they can more effectively carry out their investigations into the causes of ASD.

描述（由申请人提供）：本申请题为“开发用于自闭症谱系障碍研究的简要筛选器”，解决了广泛的挑战领域 (04) 临床研究，04-MH-101* 自闭症：应对挑战。该提案旨在开发一种基于社会沟通问卷（SCQ：Rutter、Bailey 和 Lord，2003）和自闭症诊断访谈修订版（ADI-R；Rutter、LeCouteur 和 Lord，2003）中的问题的研究筛选工具，可以更有效和更实际地应用于自闭症谱系障碍（ASD）的研究。新开发的措施将是 ADI 研究筛查问卷，这是一种简短的家长报告工具，旨在识别 2 至 18 岁儿童的自闭症谱系障碍 (ASD)。新措施的制定和验证将涉及来自美国多个地点的两组非常大的儿童。现有数据来自对自闭症谱系障碍儿童的总共 2293 项评估、对非自闭症谱系障碍儿童的 792 项评估以及 600 名患有自闭症谱系障碍儿童的典型发育兄弟姐妹，这些数据将构成措施制定样本的基础。将从正在进行的研究和专业诊断诊所中招募 1340 名 ASD 参与者、510 名非 ASD 诊断参与者以及 200 名正常发育的 ASD 儿童兄弟姐妹作为单独样本，以验证新开发的测量方法。对这两个独立样本的数据进行分析将产生一种新仪器，可用于快速确定自闭症谱系障碍研究的潜在参与者。能够快速、准确地区分自闭症谱系障碍儿童与其他发育障碍儿童的方法对于病因学和流行病学研究工作来说非常宝贵，因为它将显着减少目前指定研究参与者患有或不患有自闭症谱系障碍所需的时间和费用。开发用于自闭症谱系障碍研究的简要筛查仪 该项目将开发一种新的筛查仪器，可用于自闭症谱系障碍 (ASD) 的研究。由于需要识别大量参与者进行遗传学研究和其他自闭症谱系障碍病因调查，研究人员需要一种方法来快速筛查大量儿童并识别那些极有可能被诊断为自闭症谱系障碍的儿童。该项目将为研究人员提供快速选择潜在参与者的能力，以便他们能够更有效地开展自闭症成因的调查。