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IL-6 Regulation of Hippocampal Synaptic Function

IL-6 对海马突触功能的调节

基本信息

批准号：
7652343
负责人：
DONNA L GRUOL
金额：
$ 46.38万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-06-08 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7652343
关键词：
Acute Affect Animal Model Area Behavior Brain Brain region Central Nervous System Diseases Central Nervous System Infections Chronic Cognitive Disease Exposure to Hippocampus (Brain)Immunoblotting Impaired cognition In Vitro Inflammatory Response Injury Interleukin-6 Knowledge Learning Mediating Memory Molecular Nerve Degeneration Nervous System Physiology Neuraxis Neurodegenerative Disorders Neurons Pathway interactions Physiology Play Preparation Process Production Property Proteins Regulation Role Signal Transduction Signal Transduction Pathway Simulate Slice Synapses Synaptic Transmission Synaptic plasticity Testing Tissues Transgenic Animals Transgenic Mice Transgenic Organisms Western Blotting cognitive function cytokine in vivo insight memory encoding mouse model neuroinflammation postsynaptic presynaptic protein activation public health relevance receptor research study synaptic function

项目摘要

DESCRIPTION (provided by applicant): Neuroimmune factors have been shown to play a role in both normal CNS function and in the cognitive dysfunction associated with CNS disorders that have a neuroinflammatory component. Our knowledge about the neuronal substrates that mediate the cognitive problems associated with neuroinflammation is limited. Progress in this area will require a basic understanding of the interactions between neuroimmune factors and the cellular and molecular mechanisms that mediate normal brain function. The proposed studies focus on this issue as it relates to CNS disorders. PUBLIC HEALTH RELEVANCE: Project Narrative Neuroimmune factors have been shown to play a role in both normal CNS function and in the cognitive dysfunction associated with CNS disorders that have a neuroinflammatory component. Our knowledge about the neuronal substrates that mediate the cognitive problems associated with neuroinflammation is limited. Progress in this area will require a basic understanding of the interactions between neuroimmune factors and the cellular and molecular mechanisms that mediate normal brain function. The proposed studies focus on this issue as it relates to CNS disorders.

描述（由申请人提供）：神经免疫因子已被证明在正常中枢神经系统功能和与具有神经炎症成分的中枢神经系统疾病相关的认知功能障碍中发挥作用。我们对介导与神经炎症相关的认知问题的神经元基质的了解是有限的。这一领域的进展需要对神经免疫因子与介导正常大脑功能的细胞和分子机制之间的相互作用有基本的了解。拟议的研究重点关注这个与中枢神经系统疾病相关的问题。公共健康相关性：项目叙述神经免疫因素已被证明在正常中枢神经系统功能和与具有神经炎症成分的中枢神经系统疾病相关的认知功能障碍中发挥作用。我们对介导与神经炎症相关的认知问题的神经元基质的了解是有限的。这一领域的进展需要对神经免疫因子与介导正常大脑功能的细胞和分子机制之间的相互作用有基本的了解。拟议的研究重点关注这个与中枢神经系统疾病相关的问题。