课题基金 / 基金详情

CYTOKINE/CHEMOKINE ACTIONS ON DEVELOPING CNS NEURONS

CYTOKINE/CHEMOKINE ACTIONS ON DEVELOPING CNS NEURONS
细胞因子/趋化因子对发育中枢神经系统神经元的作用
批准号：
6388179
负责人：
DONNA L GRUOL
金额：
$27.35万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-09-01 至 2003-08-31
来源：
https://reporter.nih.gov/project-details/6388179
关键词：
IP 10 protein biological models cerebellar Purkinje cell chemokine cytokine dendrites electrophysiology glutamate receptor immunocytochemistry interleukin 1 interleukin 6 interleukin 8 laboratory rat macrophage inflammatory proteins membrane potentials neurogenesis pathologic process pediatric AIDS physical chemical interaction tissue /cell culture tumor necrosis factor alpha

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英文摘要
Description (adapted from applicant's abstract): To gain insights into the cognitive and developmental problems observed in pediatric neuroAIDS, the investigators propose to examine the effects of several cytokines and chemokines that are reported to be expressed in the CNS of HIV-1 infected patients. The investigators propose to use the cerebellar Purkinje cell culture system from embryonic rodents to determine the effects of recombinant cytokines and chemokines administered in three different modes; acute, chronic, and withdrawal. The effects will be determined by analysis of morphology, immunocytochemistry, electrophysiological recordings of various membrane ion channels and neurotransmitter receptor properties, as well as calcium imaging. By determining cytokine/chemokine-modulated changes in these parameters in developing neuronal system, the investigators wish to provide new insights into the potential roles of such factors in the CNS dysfunction in pediatric neuroAIDS.
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