IL-6 对海马突触功能的调节-猫眼课题宝

IL-6 对海马突触功能的调节

批准号：

7862325

负责人：

DONNA L GRUOL

金额：

$47.77万

依托单位：

SCRIPPS RESEARCH INSTITUTE, THE

依托单位国家：

美国

项目类别：

财政年份：

2009

资助国家：

美国

项目状态：

已结题

起止时间：

2009-06-08 至 2012-05-31

来源：

https://reporter.nih.gov/project-details/7862325

关键词：

Acute Affect Animal Model Area Behavior Brain Brain region Central Nervous System Diseases Central Nervous System Infections Chronic Cognitive Disease Exposure to Hippocampus (Brain)Immunoblotting Impaired cognition In Vitro Inflammatory Response Injury Interleukin-6 Knowledge Learning Mediating Memory Molecular Nerve Degeneration Nervous System Physiology Neuraxis Neurodegenerative Disorders Neurons Pathway interactions Physiology Play Preparation Process Production Property Proteins Regulation Role Signal Transduction Signal Transduction Pathway Simulate Slice Synapses Synaptic Transmission Synaptic plasticity Testing Tissues Transgenic Animals Transgenic Mice Transgenic Organisms Western Blotting cognitive function cytokine in vivo insight memory encoding mouse model neuroinflammation postsynaptic presynaptic protein activation public health relevance receptor research study synaptic function

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DESCRIPTION (provided by applicant): Neuroimmune factors have been shown to play a role in both normal CNS function and in the cognitive dysfunction associated with CNS disorders that have a neuroinflammatory component. Our knowledge about the neuronal substrates that mediate the cognitive problems associated with neuroinflammation is limited. Progress in this area will require a basic understanding of the interactions between neuroimmune factors and the cellular and molecular mechanisms that mediate normal brain function. The proposed studies focus on this issue as it relates to CNS disorders. PUBLIC HEALTH RELEVANCE: Project Narrative Neuroimmune factors have been shown to play a role in both normal CNS function and in the cognitive dysfunction associated with CNS disorders that have a neuroinflammatory component. Our knowledge about the neuronal substrates that mediate the cognitive problems associated with neuroinflammation is limited. Progress in this area will require a basic understanding of the interactions between neuroimmune factors and the cellular and molecular mechanisms that mediate normal brain function. The proposed studies focus on this issue as it relates to CNS disorders.

期刊论文(3)

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会议论文

Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6.

DOI： 10.1016/j.bbi.2012.05.005

发表时间： 2012-08

期刊：

BRAIN BEHAVIOR AND IMMUNITY

影响因子： 15.1

作者：

[Nelson, T. E., Engberink, A. Olde, Hernandez, R., Puro, A., Huitron-Resendiz, S., Hao, C., De Graan, P. N. E., Gruol, D. L.]