IL-6 Regulation of Hippocampal Synaptic Function

IL-6 对海马突触功能的调节

基本信息

批准号：
7862325
负责人：
DONNA L GRUOL
金额：
$ 47.77万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-06-08 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7862325
关键词：
Acute Affect Animal Model Area Behavior Brain Brain region Central Nervous System Diseases Central Nervous System Infections Chronic Cognitive Disease Exposure to Hippocampus (Brain)Immunoblotting Impaired cognition In Vitro Inflammatory Response Injury Interleukin-6 Knowledge Learning Mediating Memory Molecular Nerve Degeneration Nervous System Physiology Neuraxis Neurodegenerative Disorders Neurons Pathway interactions Physiology Play Preparation Process Production Property Proteins Regulation Role Signal Transduction Signal Transduction Pathway Simulate Slice Synapses Synaptic Transmission Synaptic plasticity Testing Tissues Transgenic Animals Transgenic Mice Transgenic Organisms Western Blotting cognitive function cytokine in vivo insight memory encoding mouse model neuroinflammation postsynaptic presynaptic protein activation public health relevance receptor research study synaptic function

项目摘要

DESCRIPTION (provided by applicant): Neuroimmune factors have been shown to play a role in both normal CNS function and in the cognitive dysfunction associated with CNS disorders that have a neuroinflammatory component. Our knowledge about the neuronal substrates that mediate the cognitive problems associated with neuroinflammation is limited. Progress in this area will require a basic understanding of the interactions between neuroimmune factors and the cellular and molecular mechanisms that mediate normal brain function. The proposed studies focus on this issue as it relates to CNS disorders. PUBLIC HEALTH RELEVANCE: Project Narrative Neuroimmune factors have been shown to play a role in both normal CNS function and in the cognitive dysfunction associated with CNS disorders that have a neuroinflammatory component. Our knowledge about the neuronal substrates that mediate the cognitive problems associated with neuroinflammation is limited. Progress in this area will require a basic understanding of the interactions between neuroimmune factors and the cellular and molecular mechanisms that mediate normal brain function. The proposed studies focus on this issue as it relates to CNS disorders.

描述（由申请人提供）：已证明神经免疫因子在正常的CNS功能和与具有神经炎症成分的CNS疾病相关的认知功能障碍中起作用。我们对介导与神经炎症相关的认知问题的神经元底物的了解是有限的。该领域的进展将需要基本了解神经免疫因子与介导正常脑功能的细胞和分子机制之间的相互作用。拟议的研究重点是与中枢神经系统疾病有关的问题。公共卫生相关性：已显示项目叙事神经免疫因子在正常的中枢神经系统功能和与具有神经炎症成分的CNS疾病相关的认知功能障碍中起作用。我们对介导与神经炎症相关的认知问题的神经元底物的了解是有限的。该领域的进展将需要基本了解神经免疫因子与介导正常脑功能的细胞和分子机制之间的相互作用。拟议的研究重点是与中枢神经系统疾病有关的问题。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6.

DOI：
10.1016/j.bbi.2012.05.005
发表时间：
2012-08
期刊：
BRAIN BEHAVIOR AND IMMUNITY
影响因子：
15.1
作者：
Nelson, T. E.;Engberink, A. Olde;Hernandez, R.;Puro, A.;Huitron-Resendiz, S.;Hao, C.;De Graan, P. N. E.;Gruol, D. L.
通讯作者：
Gruol, D. L.

Neuroimmune regulation of neurophysiology in the cerebellum.