Targeted in vivo Micro Platform for Nanodevices

用于纳米器件的靶向体内微平台

• 批准号: 7687994
• 负责人: ROGER Y TSIEN
• 金额: $ 58.21万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7687994
• 关键词: Animal Model; Binding; Biomimetics; Blood Circulation; Blood Vessels; Cancerous; Cell Survival; Cell membrane; Cells; Characteristics; Chemistry; Detection; Devices; Engineering; Erythrocytes; Heating; Homing; Image; In Vitro; Magnetism; Measurement; Methods; Modification; Morphology; Mothers; Nanostructures; Nanotubes; Numbers; Optics; Oxides; Particle Size; Peptides; Pharmaceutical Preparations; Preparation; Property; Range; Reporting; Research Personnel; Reticuloendothelial System; Rupture; Sailor; Shapes; Shipping; Ships; Silicon; Specificity; Structure; Surface; System; Testing; Toxic effect; Ultrasonics; antitumor drug; aqueous; base; biomaterial compatibility; concept; design; experience; in vivo; nano; nanodevice; nanoparticle; nanosized; nanostructured; oxidation; particle; prototype; radiofrequency; response; scaffold; seal; size; tumor

A group of investigators with complementary expertise has been assembled to construct micron-sized devices ("mother ships") that are equipped with nano-sized features and that are capable of homing into cancerous tumors in vivo and performing various tasks in the tumor. These tasks include detecting, identifying, and imaging a tumor, performing measurements on it, and delivering therapies. The system will be based on micron-sized, nanostructured porous particles composed primarily of silicon or silicon oxides. The mother ship design concept and silicon-based scaffolding were chosen for a number of reasons: (1) The micron-range size makes it possible to use silicon while retaining its unique engineering features such as optical and radiofrequency reporting properties, high-capacity nano-porous carrier structure, biocompatibility and bioresorbability; (2) This applicant group has extensive experience with nanostructured silicon microdevices, and prototype mother ship particles resembling red blood cells have already been constructed and tested in-vivo; (3) Preliminary results suggest that micron-sized particles coated with tumor-specific vascular homing peptides become lodged in tumor vasculature; (4) Micronsized particles, unlike nanoparticles, are not taken up by the reticuloendothelial system; (5) The mother ship can be extensively functionalized with nanoparticles, nanotubes, drugs, and imaging agents in a controlled fashion.

一组具有互补专业知识的研究人员已经被聚集在一起构建微米级的 装备有纳米尺寸特征并能够寻的入的装置(“母舰”) 肿瘤在体内并在肿瘤中执行各种任务。这些任务包括检测， 识别和成像肿瘤，对其进行测量，并提供治疗。系统 将基于微米大小的纳米结构的多孔颗粒，主要由硅或硅组成 氧化物。母船的设计理念和硅基脚手架被选为许多 原因：(1)微米级的尺寸使使用硅成为可能，同时保留了其独特的工程设计 光学和射频报告特性、大容量纳米多孔载体等特性 结构、生物相容性和生物再吸收能力；(2)这一申请群体具有丰富的经验 纳米结构硅微器件，以及类似红血球的母船颗粒原型 已经被构建并在体内进行了测试；(3)初步结果表明，微米级的颗粒 包被肿瘤特异性血管归巢多肽的肿瘤血管；(4)微米级 与纳米颗粒不同，颗粒不会被网状内皮系统摄取；(5)母体 船舶可以广泛地功能化与纳米颗粒，纳米管，药物和显像剂在一个 受控制的时尚。