CORE--BIOINFORMATICS

核心--生物信息学

• 批准号: 7681598
• 负责人: Bahram A. Parvin
• 金额: $ 20.74万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7681598
• 关键词: Back; Bioinformatics; Biological Assay; Characteristics; Condition; Data; Databases; Development; Ensure; Extensible Markup Language; Image; Imagery; Informatics; Measures; Molecular; Ontology; Pathway interactions; Process; Protein Microchips; Proteins; Research Infrastructure; Services; Structure; Techniques; Technology; Text; Therapeutic; base; improved; programs

The core will provide the bioinformatics infrastructure for characterizing molecular and cellular states induced by pathway interactions under different experimental conditions and therapeutic compounds. These characteristics are measured by microarrays, protein abundance, protein phosphoryiation states, and imaging assays. The core will utilize its expertise to provide an integrated view of all relevant data in databases, XML documents, and structured text ales. In addition, the core will integrate analytical applications such as routine processing of microarray data with improved normalization or clustering techniques. The informatics core will support the experimental and computational objectives by: (1) managing and administering data collected from each project and core, (2) providing ontology services, (3) developing portals for information visualization, and (4) enabling accessibility and connectivity. Development and deployment databases wilt be constructed to ensure reliability and maintain functionality.

该核心将提供生物信息学基础设施，用于表征在不同实验条件和治疗化合物下由通路相互作用诱导的分子和细胞状态。这些特征通过微阵列、蛋白质丰度、蛋白质磷酸化状态和成像测定来测量。该核心将利用其专业知识提供数据库、XML文档和结构化文本销售中所有相关数据的综合视图。此外，该核心将整合分析应用程序，如微阵列数据的常规处理与改进的标准化或聚类技术。信息学核心将通过以下方式支持实验和计算目标：（1）管理和管理从每个项目和核心收集的数据，（2）提供本体服务，（3）开发信息可视化门户，以及（4）实现可访问性和连通性。将建立开发和部署数据库，以确保可靠性和维护功能。