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Interferon regulation of T-bet in airway smooth muscle

干扰素对气道平滑肌 T-bet 的调节

基本信息

批准号：
7483034
负责人：
Cherie Singer
金额：
$ 12.54万
依托单位：
UNIVERSITY OF NEVADA RENO
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-30 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7483034
关键词：
Address Affect Award Biology Boxing CD4 Positive T Lymphocytes Cell Cycle Progression Cell Proliferation Cellular biology Commit Contractile Proteins Development Development Plans Disease Educational process of instructing Educational workshop Environment Event Faculty Foundations Goals Helper-Inducer T-Lymphocyte Inflammatory Inflammatory Response Interferon Type I Interferon Type II Interferons K-Series Research Career Programs Laboratories Mediating Mediator of activation protein Mentors Muscle Contraction Neurosciences Nevada Phenotype Postdoctoral Fellow Protein Overexpression Regulation Research Research Personnel Research Project Grants Research Training Role Services Signal Pathway Smooth Muscle Smooth Muscle Myocytes Structure Students T-bet protein Testing Thinking Universities career cytokine experience innovation instructor interest medical schools migration novel oral communication programs protein expression research and development research study respiratory smooth muscle response skills

项目摘要

DESCRIPTION (provided by applicant): A Mentored Career Development Award will allow me to become an innovative, recognized investigator and instructor by expanding my research skills, enhancing my ideas for my own research program in airway smooth muscle biology, and providing me with opportunities to continue to develop expertise in teaching through the outlined career development and research plans. I believe that my previous training and research experience at both large and small universities has given me an excellent foundation in which to begin an independent research career. As a graduate student, I endured a rigorous program of study that emphasized critical and analytical thinking, oral communication and presentation skills, and research excellence in the neurosciences. As a post-doctoral fellow, I developed an interest in the role of airway smooth muscle (ASM) in inflammatory events that contribute to airway diseases and took advantage of opportunities to gain teaching experience. I continue my interest in airway smooth muscle biology with this proposal by examining the T-box transcription factor T-bet in ASM. The proposed career development plan will facilitate my goals through intellectual interactions with colleagues, students and my mentor, Dr. William T. Gerthoffer, along with participation in structured activities including University service, attendance at scientific meetings, and involvement in teaching, career development and laboratory management workshops and seminars. The research project described here examines the hypothesis that ASM expression of T-bet participates in the development of a secretory smooth muscle cell phenotype that affects the inflammatory response by increasing T helper cell 1 (Th1) cytokine secretion. The experiments described will examine IFNgamma regulation of T-bet expression in ASM, determine whether T-bet expression contributes to the development of a secretory smooth muscle cell phenotype by upregulating Th1 cytokines, and addresses whether T-bet alters the functions of ASM cells such as proliferation, migration and contraction. There are few places that I would have the opportunity to interact with faculty that are as recognized for their expertise in smooth muscle cell biology than at the University of Nevada School of Medicine. This award will allow me to begin to ask novel questions about the secretory phenotype of ASM in this supportive research environment that is committed to furthering junior faculty development.

描述（由申请人提供）：一个指导职业发展奖将使我成为一个创新的，公认的调查员和讲师，通过扩大我的研究技能，提高我的想法，我自己的研究计划在气道平滑肌生物学，并为我提供机会，继续发展专业知识，通过概述的职业发展和研究计划的教学。我相信我以前在大型和小型大学的培训和研究经验为我开始独立的研究生涯奠定了良好的基础。作为一名研究生，我经历了一个严格的学习计划，强调批判性和分析性思维，口头交流和演讲技巧，以及在神经科学方面的卓越研究。作为一名博士后研究员，我对气道平滑肌（ASM）在导致气道疾病的炎症事件中的作用产生了兴趣，并利用机会获得了教学经验。我继续我的兴趣在气道平滑肌生物学与此建议，通过检查T盒转录因子T-bet在ASM。建议的职业发展计划将通过与同事、学生和我的导师威廉·T博士的智力互动来促进我的目标。Gerthoffer，沿着参加结构化活动，包括大学服务，出席科学会议，并参与教学，职业发展和实验室管理讲习班和研讨会。这里描述的研究项目检查了T-bet的ASM表达参与分泌性平滑肌细胞表型的发展的假设，该表型通过增加T辅助细胞1（Th 1）细胞因子分泌来影响炎症反应。所描述的实验将检查IFN γ对ASM中T-bet表达的调节，确定T-bet表达是否通过上调Th 1细胞因子而有助于分泌性平滑肌细胞表型的发展，并解决T-bet是否改变ASM细胞的功能，例如增殖、迁移和收缩。有几个地方，我会有机会与教师互动，是公认的专业知识，在平滑肌细胞生物学比在内华达州医学院的大学。这个奖项将使我开始问新的问题，分泌表型的ASM在这个支持性的研究环境，致力于促进初级教师的发展。