CORTICOTHALAMIC INPUT TO THE MOTOR THALAMUS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的目标是确定在帕金森病的非人类模型中发生的丘脑运动放电的变化，例如由MPTP或鱼藤酮毒素引起的变化，以及这些放电变化发生的行为条件。 利用MPTP诱导的帕金森病模型，我们研究了在训练的定向到达任务的不同阶段(和不同的注意要求)以及MPTP诱导的残疾的不同阶段丘脑神经元的突发性。在不同的行为状态下，记录了500多个丘脑神经元的活动。如果识别出低阈值钙爆发(LTS)，并确定了这些爆发中尖峰的百分比，那么严重受损的动物的突发性会增加，但轻度受损的动物则不会那么严重。 进一步的分析，包括具有不同程度突发性的神经元的位置以及不同类型的放电不规则和振荡正在进行中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our objective is to determine the changes in discharge in the motor thalamus that occur in non-human models of Parkinson's disease, such as those induced by the toxins MPTP or rotenone, and the behavioral conditions under which these changes in discharge occur. Using the MPTP-induced model of Parkinson's disease, we have examined the burstiness of neurons in the thalamus during different phases (and different attention requirements) in a trained targeted reaching task and during different phases of MPTP-induced disability. The activity of over 500 thalamic neurons has been recorded during different behavioral states. If low-threshold calcium bursts (LTS) are identified and the percent of spikes in these bursts is determined, there is an increase in burstiness in severely impaired animals, but not so much in mild impairment. Further analysis, including the location of neurons with different degrees of burstiness and the different types of discharge irregularity and oscillations is under way.