FUNCTIONAL ORGANIZATION OF CERVICAL SPINAL INTERNEURONS

颈椎中间神经元的功能组织

• 批准号: 7716365
• 负责人: Steve I Perlmutter
• 金额: $ 17.37万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716365
• 关键词: Cervical; Computer Retrieval of Information on Scientific Projects Database; Data; Data Analyses; Forearm; Funding; Grant; Hand; Institution; Interneurons; Journals; Manuscripts; Monkeys; Motor Cortex; Motor Neurons; Movement; Muscle; Neurons; Neurosciences; Performance; Preparation; Primates; Relative (related person); Research; Research Personnel; Resources; Role playing therapy; Signal Transduction; Site; Source; Spinal; Spinal Cord; United States National Institutes of Health; Upper arm; grasp; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Research focused on three projects during this year. 1. The control of motoneurons by short propriospinal neurons in the primate. Data analysis was completed and a manuscript is in final preparation for submission to the Journal of Neuroscience. The main conclusion from this study is that many that neurons in the C3-C4 spinal segments have extensive activity related to arm movements. 2. The directional tuning of neurons in motor cortex for hand movements. Data was collected from two monkeys during performance of a multi-dimensional hand task. Many neurons are directionally tuned and the results, which is currently being analyzed, will be compared to those from spinal interneurons recorded during the same tasks. This comparison will elucidate the relative roles played by motor cortex and spinal cord in generating signals to control forearm muscles. 3. Movements evoked by intraspinal stimulation. We have initiated a new direction in the project that will determine the feasibility of developing neuroprosthetics that employ spinal stimulation to produce functional movements. We completed an initial study that identified sites from which particular hand and arm movements can be elicited with intraspinal microstimulation. These experiments demonstrated that many movements, particularly grasping of the hand, can be produced by stimulation at single sites in the cervical cord.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 今年的研究重点是三个项目。 1. 灵长类动物脊髓短本体神经元对运动神经元的控制。 数据分析已经完成，手稿正在最后准备提交给神经科学杂志。 这项研究的主要结论是，C3-C4脊髓节段中的许多神经元具有与手臂运动相关的广泛活动。 2. 运动皮层神经元对手部运动的定向调控。 数据收集从两只猴子在性能的多维手的任务。 许多神经元是定向调谐的，目前正在分析的结果将与在相同任务期间记录的脊髓中间神经元的结果进行比较。 这种比较将阐明运动皮层和脊髓在产生控制前臂肌肉的信号中所起的相对作用。 3. 脊柱内刺激引起的运动。 我们已经在该项目中启动了一个新的方向，该方向将确定开发利用脊柱刺激来产生功能性运动的神经修复术的可行性。 我们完成了一项初步研究，确定了特定的手和手臂运动可以引起脊柱内微刺激的网站。 这些实验表明，许多运动，特别是手的抓握，可以通过刺激颈髓中的单个部位来产生。