FUNCTIONAL ORGANIZATION OF CERVICAL SPINAL INTERNEURONS

颈椎中间神经元的功能组织

• 批准号: 8357605
• 负责人: Steve I Perlmutter
• 金额: $ 15.66万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357605
• 关键词: Animal Experiments; Animals; Behavior; Biomedical Engineering; Cerebellum; Cervical; Cervical spinal cord structure; Collaborations; Data; Dependence; Devices; Electrodes; Funding; Grant; Hand; Implant; Interneurons; Israel; Monkeys; Movement; Muscle; National Center for Research Resources; Nerve; Neurons; Output; Pathway interactions; Primates; Principal Investigator; Property; Research; Research Infrastructure; Resources; Series; Source; Spinal; Stimulus; Structure of nucleus cuneatus; Training; United States National Institutes of Health; Universities; Wrist; arm; cost; grasp; limb movement; research study; response; spine bone structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Two sets of new experiments began during the last year. 1. The task-dependence of the output effects of intraspinal stimulation are being investigated. A monkey was trained on a wrist task and a reach-and-grasp task, and muscle and nerve electrodes were implanted; a vertebral device will be implanted soon. Electrical stimuli will be delivered to the intermediate and ventral laminae of the cervical spinal cord as the animal performs the trained tasks. Differences in the responses of arm muscles during the different tasks will elucidate features of spinal organization controlling voluntary limb movements. 2. Initial recording in the external cuneate nucleus are underway. This study will examine the properties of neurons relaying proprioceptive information from the arm and hand to the cerebellum during voluntary movements. In collaboration with data collected by Dr. Yifat Prut (Hebrew University, Jerusalem, Israel), we will elucidate the type of information carried by spinocerebellar pathways during normal behavior. In addition, a new series of experiments on the responses of cervical spinal interneurons to perturbations of the wrist and hand is being set up. The Primate Center Bioengineering Core is constructing a new apparatus for use in these experiments and an animal is being trained. We hope to start these experiments during the next year.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 去年开始了两组新的实验。 1. 椎管内刺激输出效应的任务依赖性正在研究中。 一只猴子接受了手腕任务和伸手抓握任务的训练，肌肉和神经电极被植入;脊椎装置将很快被植入。 当动物执行训练任务时，电刺激将被传递到颈脊髓的中间层和腹侧层。 在不同的任务手臂肌肉的反应的差异将阐明脊柱组织控制随意肢体运动的功能。 2. 外楔束核的初步记录正在进行中。 本研究将探讨在随意运动过程中，从手臂和手到小脑传递本体感受信息的神经元的特性。 与Yifat Prut博士（以色列耶路撒冷希伯来大学）收集的数据合作，我们将阐明正常行为期间脊髓小脑通路所携带的信息类型。 此外，一个新的系列实验的反应，颈脊髓interneurons的扰动的手腕和手正在成立。 灵长类动物中心生物工程核心正在建造一种用于这些实验的新设备，一只动物正在接受训练。 我们希望在明年开始这些实验。