FUNCTIONAL ORGANIZATION OF CERVICAL SPINAL INTERNEURONS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 去年开始了两组新的实验。 1.对脊髓内刺激输出效应的任务依赖性进行了研究。一只猴子接受了手腕任务和伸手抓握任务的训练，肌肉和神经电极被植入；脊椎装置很快就会被植入。当动物执行训练任务时，电刺激将被传递到颈髓的中间和腹板。手臂肌肉在不同任务中反应的不同将阐明控制肢体自由运动的脊柱组织的特征。 2.楔状外核的初步记录正在进行中。这项研究将研究在随意运动过程中，将本体感觉信息从手臂和手传递到小脑的神经元的特性。与Yifat Prut博士(希伯来大学，以色列耶路撒冷)收集的数据合作，我们将阐明正常行为中脊髓小脑通路携带的信息类型。 此外，一系列关于颈脊髓中间神经元对手腕和手部扰动的反应的新实验正在建立中。灵长类动物中心生物工程核心正在建造一种新的仪器，用于这些实验，一只动物正在接受训练。我们希望在明年开始这些实验。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Two sets of new experiments began during the last year. 1. The task-dependence of the output effects of intraspinal stimulation are being investigated. A monkey was trained on a wrist task and a reach-and-grasp task, and muscle and nerve electrodes were implanted; a vertebral device will be implanted soon. Electrical stimuli will be delivered to the intermediate and ventral laminae of the cervical spinal cord as the animal performs the trained tasks. Differences in the responses of arm muscles during the different tasks will elucidate features of spinal organization controlling voluntary limb movements. 2. Initial recording in the external cuneate nucleus are underway. This study will examine the properties of neurons relaying proprioceptive information from the arm and hand to the cerebellum during voluntary movements. In collaboration with data collected by Dr. Yifat Prut (Hebrew University, Jerusalem, Israel), we will elucidate the type of information carried by spinocerebellar pathways during normal behavior. In addition, a new series of experiments on the responses of cervical spinal interneurons to perturbations of the wrist and hand is being set up. The Primate Center Bioengineering Core is constructing a new apparatus for use in these experiments and an animal is being trained. We hope to start these experiments during the next year.