ROLE EPIGENETICS DIFFERENTIAT OF HUMAN EMBRYONIC STEM CELLS INTO VASCUL LINEAGES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的具体目标摘要。 该项目的具体目标是： 目的1.明确DNA甲基化和组蛋白乙酰化介导的基因调控在人胚胎干细胞(HESC)向血管平滑肌细胞(VSMC)分化中的作用。 目的2.明确DNA甲基化和组蛋白乙酰化介导的基因调控在人胚胎干细胞(HESC)向内皮细胞(EC)分化过程中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Summary of the specific aims of the project. The specific aims of the project were: Aim 1. Define the role of DNA methylation- and histone acetylation-mediated regulation of genes in the differentiation of human embryonic stem cells (hESC) into vascular smooth muscle cells (VSMC). Aim 2. Define the role of DNA methylation- and histone acetylation-mediated regulation of genes in the differentiation of human embryonic stem cells (hESC) into endothelial cells (EC).