ROLE EPIGENETICS DIFFERENTIAT OF HUMAN EMBRYONIC STEM CELLS INTO VASCUL LINEAGES

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 项目的具体目标摘要。 该项目的具体目标是： 目标1.明确DNA甲基化和组蛋白乙酰化介导的基因调控在人胚胎干细胞（hESC）分化为血管平滑肌细胞（VSMC）中的作用。 目标2. 明确DNA甲基化和组蛋白乙酰化介导的基因调控在人胚胎干细胞（hESC）分化为内皮细胞（EC）中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Summary of the specific aims of the project. The specific aims of the project were: Aim 1. Define the role of DNA methylation- and histone acetylation-mediated regulation of genes in the differentiation of human embryonic stem cells (hESC) into vascular smooth muscle cells (VSMC). Aim 2. Define the role of DNA methylation- and histone acetylation-mediated regulation of genes in the differentiation of human embryonic stem cells (hESC) into endothelial cells (EC).