Targeting Therapeutic Gene Vectors to Reactive Glia

将治疗性基因载体靶向反应性神经胶质细胞

• 批准号: 7586677
• 负责人: JIANFENG XU
• 金额: $ 5.86万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-26 至 2010-03-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7586677
• 关键词: Animal Model; Astrocytes; Basic Science; Brain; Brain Diseases; Capsid; Capsid Proteins; Engineering; Epitopes; Gene Expression; Gene Targeting; Gene-Modified; Generations; Genes; In Vitro; Ischemia; Modeling; Neuroglia; Neurons; Rattus; Role; Satellite Viruses; Specificity; Testing; Therapeutic; Transient Cerebral Ischemia; adeno-associated viral vector; chemokine receptor; cytokine; efficacy evaluation; in vivo; injured; nervous system disorder; neuron loss; novel; receptor binding; response; small hairpin RNA; targeted delivery; therapeutic gene; tool; vector

DESCRIPTION (provided by applicant): The objective of this proposal is to generate a novel set of targeted gene vectors with specificity for reactive glial cells, which will serve as valuable tools for basic research into the mechanisms underlying multiple brain disorders as well as vehicles for potential therapy, and test them in a specific first application to a standard animal model of ischemia.

描述(申请人提供)：这项建议的目标是产生一套新的具有反应性神经胶质细胞特异性的靶向基因载体，将作为基础研究的有价值的工具，以研究多发性脑疾病的潜在机制以及潜在的治疗工具，并在标准动物缺血模型中进行特定的首次应用。