Targeting Therapeutic Gene Vectors to Reactive Glia

将治疗性基因载体靶向反应性神经胶质细胞

• 批准号: 7158017
• 负责人: JIANFENG XU
• 金额: $ 5.8万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-26 至 2010-03-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7158017
• 关键词: astrocytes; brain disorders; capsid; genes; glia; model

DESCRIPTION (provided by applicant): The objective of this proposal is to generate a novel set of targeted gene vectors with specificity for reactive glial cells, which will serve as valuable tools for basic research into the mechanisms underlying multiple brain disorders as well as vehicles for potential therapy, and test them in a specific first application to a standard animal model of ischemia.

描述（由申请人提供）：本提案的目的是产生一组新的对反应性神经胶质细胞具有特异性的靶向基因载体，其将作为对多种脑疾病的潜在机制进行基础研究的有价值的工具以及潜在治疗的载体，并在标准缺血动物模型的特定首次应用中对其进行测试。